Delayed catabolism of apoB-48
lipoproteins due to decreased heparan sulfate proteoglycan production in diabetic mice.
There are two forms of the ApoB protein, apoB-100 and apoB-48
, resulting from tissue-specific alternative splicing.
ApoB gene expresses in two isoforms as ApoB-48
in chylomicron and ApoB-100 in the liver.
Infusion of GLP-1 (20 pmol/kg/min) via jugular vein reduces triacylglycerol absorption and intestinal ApoB-48
production in rats .
O quilomicrom doa apoA e apoC para as particulas de HDL, ficando com a apoB-48
e apoE e muito colesterol, o qual e levado de volta ao figado e gracas a apoE sera captado por receptores especializados (Lima, 2009; Smith, Marks e Lieberman, 2007)
ApoB is found on chylomicrons (apoB-48
), VLDL, IDL, LDL, and Lp(a) but is not reported to be contained on LpX.
Early alterations in the postprandial VLDL1 apoB-100 and apoB-48
metabolism in men with strong heredity for type 2 diabetes.
To measure chylomicron remnants, we have employed a sensitive Western Blot and Enhanced Chemiluminescence Assay, to quantify apolipoprotein B-48 (apoB-48
), a protein found exclusively on chylomicron remnants and their precursor (23).
The APOB gene is located on chromosome 2 and produces, via a unique mRNA editing process, two forms of apoB in circulating lipoproteins, apoB-48
and apoB-100 (3).
Triglycerides of dietary origin enter the circulation as chylomicrons, the largest of lipoprotein particles (80-1000 nm) packaged together with the truncated form of apolipoprotein B, apoB-48
, whereas fatty acids originating in the liver are secreted as VLDL (25-80 nm) with apoB-100.