apoenzyme

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apoenzyme

[¦a·pō¦en‚zīm]

(biochemistry)

The protein moiety of an enzyme; determines the specificity of the enzyme reaction.

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References in periodicals archive ?

The patient group was restricted to patients with complete apoenzyme deficiency (termed [mut.sup.0] in MMA).

Metabolomics identifies perturbations in human disorders of propionate metabolism

The apoenzyme stimulation tests for vitamin B1, B2 and B6 adapted to the Cobas Bio analyzer.

Pyridoxal phosphate decreases in plasma but not erythrocytes during systemic inflammatory response

In brief, 0.2 mL each of holoenzyme (3.75 g/L) and apoenzyme (1.0 g/L) was added to 0.2 mL of 0.8 mol/L perchloric acid.

Homogeneous, nonradioactive, enzymatic assay for plasma pyridoxal 5-phosphate

These include loss of reactivatable apoenzyme during chronic deficiency in vivo (7, 8), altered binding of apoenzyme and coenzyme because of the presence of isoenzymes of transketolase (9), and reduced synthesis of apoenzyme in patients with diabetes (10) and liver disease (11).

Vitamin [B.sub.1] status assessed by direct measurement of thiamin pyrophosphate in erythrocytes or whole blood by HPLC: comparison with erythrocyte transketolase activation assay

The cblE class may involve a reducing component of the MS system (84), whereas cblG is thought to be caused by defective MS apoenzyme (85,86).

Homocysteine and vitamins in cardiovascular disease

Biotin, pyridoxal-phosphate, and riboflavin can be covalently bound to the apoenzymes and are called prosthetic groups.