A major component in the hepatic synthesis of very low-density lipoprotein (VLDL) and hence LDL, is the transcription and translation of
apolipoprotein B-100 (apo B100), the carrier protein of LDL.
No reports describing the use of mipomersen (Kynamro), an oligonucleotide inhibitor of
apolipoprotein B-100 synthesis, in human pregnancy have been located.
Total cholesterol, HDL-c, TG, Apolipoprotein A-1 (Apo A-1),
Apolipoprotein B-100 (Apo B-100) and glucose were measured in serum by standardized enzymatic automated methods in a PENTRA-400 autoanalyzer (ABX-Horiba Diagnostics, Montpellier, France).
The complete cDNA and amino acid sequence of human
apolipoprotein B-100. J.
The Kynamro injection is an oligonucleotide inhibitor of
apolipoprotein B-100 synthesis and has been approved in the US for use in patients with homozygous familial hypercholesterolemia, a genetic disease characterised by extreme cholesterol levels.
Kynamro is an oligonucleotide inhibitor of
apolipoprotein B-100 synthesis.
Serum
apolipoprotein B-100 concentrations in healthy and diseased cattle.
VLDL is assembled on
apolipoprotein B-100 (apoB100) and comprises 50% TG, 20% cholesterol esters, 15% phospholipids and 15% protein.
Lp (a) is an LDL-like particle having an apolipoprotein (a) which is attached to
apolipoprotein B-100 by a disulfide linkage.
Apolipoprotein B-100 gene Xba I polymorphism and cholesterol gallstone disease.
In this paper, we first review LDL,
apolipoprotein B-100, the unique protein of LDL, and its oxidation sensitive components.