test in parkinsonian syndromes [1, 3] gives a response within 15-30 minutes and may thus have a time advantage over the levodopa test.
sublingual film, a novel formulation of the dopamine agonist apomorphine
, is being developed as a fast-acting medicine for the on-demand treatment of all types of motor OFF episodes, which occur when PD symptoms, otherwise controlled by medications, re-emerge.
, who investigated the directions of rotation that were induced by either apomorphine
or amphetamine in partially and severely lesioned animals.
After pretreatment with trimethobenzamide, an antiemetic, they were randomized double blind to treatment of an acute off episode using 4 mg of apomorphine
or a placebo injection, then crossed over to the other study arm for treatment of another episode on a separate day.
His team didn't look at it in this study because they knew the dopamine boost from apomorphine
or the placebo doesn't last any longer than the patients' time in the imaging machine.
is a dopamine agonist (mimic) that acts centrally in a region of the brain that controls pathways involved in dopamine production and release.
(5) confirmed that resting energy expenditure was increased in patients with Parkinson's disease before and after treatment with apomorphine
. They found that energy expenditure was significantly higher in the untreated state for a subgroup of patients showing marked rigidity relieved by apomorphine
M2 PHARMA-February 2, 2018-Sunovion Apomorphine
Sublingual Film Meets Primary and Secondary Endpoints in Parkinson's Disease Patients
Valeritas Holdings announced results from a preclinical pharmacokinetic study of apomorphine
subcutaneous infusion delivered via its h-Patch wearable drug delivery device.
Longer latencies have been reported in brainstem lesions, stimulation of the substantia nigra, and after administration of nicotine or D2 receptor agonists (apomorphine
) (17) or serotonin antagonists (18).
Effects of visual sexual stimuli and apomorphine
SL on cerebral activity in men with erectile dysfunction.
I examined the terrier and felt it best to give emetic apomorphine
to try to make him vomit everything up before doing anything more invasive.