apoptosis


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apoptosis

[‚ā·pō′tō·səs]
(cell and molecular biology)
Death of cells triggered by extracellular signals or genetically programmed events, carried out by processes within the cell, and characterized by systemic breakdown of cellular constituents, in particular chromosomal deoxyribonucleic acid; may be involved in normal development and aging, or may serve to eliminate defective or damaged cells. Also known as programmed cell death.
References in periodicals archive ?
Numerous studies suggest that for the removal of somatic and germ cells in the ovaries of mammals and birds, apoptosis is the mean molecular mechanism (Kumar and Joy, 2015; Chatterjee and Bhattacharjee, 2016).
Statins inhibit 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, the rate-determining enzyme in the multistep mevalonate cascade for cholesterol synthesis.[17] Statins are widely used in the prevention of cardiovascular disease by lowering cholesterol.[17] Beyond their cholesterol reduction effect, statins have been shown to have pleiotropic effects.[15],[16],[17] Accumulating evidences indicated that the inhibition of the mevalonate pathway by statins induced ER stress and apoptosis in cancerous and noncancerous cells.[17],[18],[19],[20] In this study, we explored the beneficial effect of simvastatin on ox-LDL-induced ER stress and apoptosis in human vascular endothelial cells.
Positive Annexin V staining indicated early apoptosis, and positive PI staining indicated binding to DNA which occurred when cell membranes disintegrated.
Persistence of HCV infection and consequent HCC is greatly attributed to the inhibition of apoptosis and studies indicate that HCV proteins have pro and anti-apoptotic properties 5,6.
Keywords: Autoimmune disease, Dry eye, Impression cell, Apoptosis.
Prostate apoptosis response 4 (Par-4) is considered a proapoptotic factor.
have successfully identified the mechanism of mtDNA efflux during apoptosis [14].
The results of this study revealed that luteolin induced apoptosis and autophagy of the mouse macrophage ANA-1 cells via altering the cell viability and DNA fragment.
miRNAs regulate organism development, cellular differentiation and proliferation, and cell apoptosis and death (Andreas et al., 2016; Pan, Toms, Shen, and Li, 2015; Xu, Linher-Melville, Yang, Wu, and Li, 2011).
Dr Stephen Tait, of the Cancer Research UK Beatson Institute, Institute of Cancer Sciences, said: "Our research found that triggering Caspase-Independent Cell Death (CICD), but not apoptosis, often led to complete tumour regression.
It then activates downstream caspases (such as caspase-3) and leads to apoptosis [23].