One of the major mechanisms of sepsis-induced immunosuppression is due to apoptosis
of the cells of the adaptive immune system (5).
es una forma controlada de muerte celular que sirve como mecanismo regulador de diversos procesos biologicos.
The fragments were fixed, embedded in paraffin, and cut into serial 5-[micro]m-thick sections that were used for confirmation of the diagnosis, immunohistochemistry for the detection of TNF-[alpha], IFN-[gamma], Bcl-2, Fas, and iNOS, and detection of apoptosis
by the terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL) technique.
Programmed death is the feature that distinguishes apoptosis
from the accidental death of necrosis.
Aegera has taken this technology to the clinic with an antisense therapeutic, AEG35156, targeting just one of their IAPs named the X-linked inhibitor of apoptosis
(XIAP) protein, a target which inhibits apoptosis
using duel mechanisms.
An advantage of this test is that it measures cellular material released into the circulation by dying or dead cancer cells as a result of apoptosis
In vitro apoptosis
in individual cells was determined by terminal desoxyriboxyl-desoxyriboxyl transferase-mediated DVTP nick-end labeling (TUNEL) assay with the In Situ Cell Death Assay Kit (Roche Diagnostic Corp.
By reawakening the apoptosis
that seems to fail in many tumor cells, J.
Quite distinctive from necrosis is a second method of cell death, apoptosis
, which is a highly regulated and systematic form of programed cell death [8, 9].
first generation indirect apoptogens (established drugs such as cytotoxics which have turned out to rely on apoptosis
for part of their efficacy)
is a recognized mechanism for the elimination of redundant cells, although it may also inhibit cell proliferation.
In a process called apoptosis
, many damaged or no-longer-needed cells kill themselves.