arachidonate


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Related to arachidonate: Phosphatidate

arachidonate

[‚a¦rak·ə¦dän‚āt]
(biochemistry)
A salt or ester of arachidonic acid.
References in periodicals archive ?
Cyclooxygenase (COX), arachidonate lipoxygenase (ALOX), and CYP450 epoxygenases enzymes use the AA as a primary precursor, generating eicosanoids including prostaglandins, leukotrienes, epoxyeicosatrienoic acids (EETs), and hydroperoxyeicosatetraenic acids (HPETEs) [65].
Laposata, "Covalent modification of proteins by arachidonate and eicosapentaenoate in platelets," Journal of Biological Chemistry, vol.
[10] Furthermore, it is shown to influence platelet production and aggregation by activating arachidonate 12-lipoxygenase (ALOX 12) and platelet-activating factor receptor (PTAFR) genes.
Some asthma agents, such as montelukast, act as either leukotriene-related enzyme inhibitors (arachidonate 5-lipoxygenase) or leukotriene receptor antagonists.
Chatgilialoglu, "Arachidonate geometrical isomers generated by thiyl radicals: The relationship with trans lipids detected in biological samples," Free Radical Biology and Medicine, vol.
Myers, "Inhibition of arachidonate 5-lipoxygenase triggers massive apoptosis in human prostate cancer cells," Proceedings of the National Academy of Sciences of the United States of America, vol.
Salloignon et al., "Glycated albumin with loss of fatty acid binding capacity contributes to enhanced arachidonate oxygenation and platelet hyperactivity: relevance in patients with type 2 diabetes," Diabetes, vol.
Shelhamer, "Dexamethasone alters arachidonate release from human epithelial cells by induction of p11 protein synthesis and inhibition of phospholipase A2 activity," Journal of Biological Chemistry, vol.
Although both COX isoenzymes catalyze the oxygenation of arachidonate, COX-2 shows a more diverse substrate selectivity compared to COX-1.
Sakamoto et al., "Arachidonate 12/15-lipoxygenase-induced inflammation and oxidative stress are involved in the development of diabetic cardiomyopathy," Diabetes, vol.