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In this study, the TRP channel agonists capsaicin, RN1747, and arachidonic acid stimulated bioluminescence in L.
As an advantage, licofelone has no gastric toxicity when compared to the selective inhibitor drugs that take role in both arachidonic acid pathways (Narayanan et al., 2007).
Platelets do not express 5-LO but express high levels of the 12-LO enzyme which is responsible for the conversion of arachidonic acid into 12-hydroxyeicosatetraenoic acid (12-HETE), an inflammatory lipid mediator implicated in vascular permeability.
Hereby, it has to be emphasized that in all cases arachidonic acid is first transformed to unstable precursor intermediate molecules ending up to many "S" conformations after aspirin treated COX-2 [30,41].
Roux et al., "An isolation procedure for arachidonic acid producing Mortierella species," Antonie van Leeuwenhoek, vol.
Efficacy and safety of arachidonic acid for treatment of Schistosoma mansoni-infected children in Menoufiya, Egypt.
In our study PUFA was of great interest as most of the long chain fatty acid cannot be synthesized easily by human body like eicosapentaenoic acid (EPA; 20:53) arachidonic acid (AA; 20:46) and docosahexaenoic acid (DHA; 22:63).
Among the physiological activators of platelet, thromboxane A [sub]2 (TXA [sub]2 ) is the primary one which is conversed from arachidonic acid in the platelets and catalyzed by cyclooxygenase (COX).
Lipoxins (such as lipoxin A4 and lipoxin B4) are unique structures derived from arachidonic acid that have potent actions in vivo and in vitro (Figure-1).
The EPA and DI-IA of omega-3 fatty acids become prostaglandins, while omega-6 fatty acids include arachidonic acid (AA), which moves through the pathway to become a thromboxane.
Dulbecco's modified eagle medium (DMEM), L-glutamine, lipopolysaccharide (LPS), 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT), arachidonic acid, acetic acid, dexamethasone, and phosphate buffer saline were purchased from (Sigma, USA); penicillin/streptomycin, TypLE (GIBCO, USA), fetal bovine serum, Griess reaction (Invitrogen, USA), Interferon-gamma (IFN-[gamma]) (Biolegend, USA), acetyl salicylic acid (ASA) (local pharmacy), 96-microtitre plate (TPP, Switzerland), serological pipettes, T-25 flasks, and 15 mL tubes (Corning, USA) were used.