aristolochic acid


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aristolochic acid

[ə¦ris·tə¦läk·ik ′as·əd]
(organic chemistry)
C17H11NO7 Crystals in the form of shiny brown leaflets that decompose at 281-286°C; soluble in alcohol, chloroform, acetone, ether, acetic acid, and aniline; used as an aromatic bitter. Also known as aristolochine.
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Second, the lack of some clinicopathological parameters of the study cohort such as accurate information on aristolochic acid medication history, surgical margin status, and lymphovascular invasion status which may reduce the strength of this study.
Wang, "Population-based case-control study of chinese herbal products containing aristolochic acid and urinary tract cancer risk," Journal of the National Cancer Institute, vol.
The paper indicates that regulatory measures that have so far been adopted by national and international agencies may be inadequate in preventing harmful exposure to aristolochic acid. The compound is linked to many cases of kidney diseases and urothelial cancer, a form of cancer of which bladder cancer is the most known variant.
Nearer to home, an epidemic of kidney disease plus cancer affecting thousands of patients in the Danube basin was laid at the door of aristolochic acid.
Aristolochic acid was banned from herbal supplements and weight loss remedies after it was found to cause cancer.
The only supplement listed as "Definitely Hazardous," aristolochic acid, often is marketed as a premenstrual syndrome remedy or a heart disease treatment under such names as PMS-Ease and Cardioflex.
For example, she said, aristolochic acid is not produced in the United States and the federal government has an import ban on it, so if the law were being enforced it would not be available for sale here.
Dirty Dozen: 12 Supplements to Avoid Name(s) Dangers Regulatory Actions DEFINITELY HAZARDOUS: Documented organ failure or known carcinogenic properties Aristolochic acid Potent human FDA warning to (Aristolochia, carcinogen; kidney consumers and birthwort, snakeroot, failure, sometimes industry and import snakeweed, sangree requiring transplant; alert in April 2001.
"If you don't ask, you won't be told." Dirty Dozen: 12 Supplements to Avoid Name(s) Dangers Regulatory Actions DEFINITELY HAZARDOUS: Documented organ failure or known carcinogenic properties Aristolochic acid Potent human carcinogen; FDA warning to (Aristolochia, birthwort, kidney failure, consumers and snakeroot, snakeweed, sometimes requiring industry and import sangree root, sangrel, transplant; deaths alert in April serpentary, serpentaria, reported.
Included among the products that will almost surely face increased scrutiny are bitter orange, or citrus aurantium; usnic acid; and aristolochic acid. All three have been used as weight-loss aids, while aristolochic acid has also been used to alleviate gastrointestinal and other health problems.