The exothermic heat was used to calculate the aromatization
index as shown in Table 4 according to the following formula:
In contrast, the Co, Ni, and Zn chlorides decrease the yields of methane, ethane, ethene and propane, and increase those of propene, butane and butene, which may be related to the aromatization
of aliphatic hydrocarbons.
Moreover, the log E2/T ratio was calculated to estimate the extent in which extragonadal aromatization
could explain the recovery of serum E2 levels [20, 30].
Ghosh, "Oxidative aromatization
of Hantzsch 1,4-dihydropyridines by cupric bromide under mild heterogeneous condition," Tetrahedron Letters, vol.
The biosynthesis of estrogen is performed by the aromatase enzyme by the process of conversion or aromatization
of androgens (C19) to estrogens (C18).
Results suggest that castration in males significantly increased the levels of serum [E.sub.2], possibly due to extragonadal aromatization
in adipose tissue .
Its metabolite DHD (20-a-dihydrogesterone) has progestin like activity, no aromatization
Most estrogen in men is produced through the aromatization
(conversion) of testosterone to estrogen in the body.
Explanation of this phenomenon may be (1) aromatization
of exogenous androgen to estrogen, and (2) inhibition of the biosynthesis of the endogenous androgen in genotypic males (Piferrer and Donaldson, 1991; Hornung et al., 2004).
Aromatase inhibitors suppress estrogen production in both ovaries and the brain by inhibiting aromatization
which releases the hypothalamic/ pituitary axis of estrogenic negative feedback that increases gonadotropin secretion, resulting in stimulation of ovarian follicles.
Histological examinations of the tamoxifen and letrozole treated gonads showed well differentiated testicular cells showing spermatozoa in seminiferous tubules suggesting that the sex reversal was male hormone (testosterone) based since letrozole blocked the aromatization
process [12,37] while tamoxifen inhibited receptor binding.
During the reproductive years estradiol (E2) in women is produced mainly by the granulosa cells of the ovaries through the aromatization
of androstenedione to estrone.