The result of this first high-throughput screen was Arsphenamine
(also known as Salvarsan), a drug whose effectiveness was nothing short of stunning for its time.
Paul Erhlich, the Nobel laureate famed for groundbreaking work ira hematology and immunology, coined the term chemotherapy and discovered arsphenamine
(Salvarsan), a form of arsenic and the first chemotherapeutic agent for systemic treatment of a microorganism.
According to the Food and Drug Administration (FDA), "Biological product means a virus, therapeutic serum, toxin, antitoxin, vaccine, blood, blood component or derivative, allergenic product, or analogous product, or arsphenamine
or derivative of arsphenamine
(or any other trivalent organic arsenic compound), applicable to the prevention, treatment, or cure of a disease or condition of human beings" (U.
One of the early chemicals developed by Ehrlich which was both remarkably nontoxic to humans and remarkably toxic against a number of treponemal diseases (including syphilis and yaws) was the arsenical compound, Salvarsan arsphenamine
, which was also called the "magic bullet".