The following findings do not exclude the application of CARTS terminology for reasons that are further clarified below: the absence of morphologic HS (although frequently present), the absence of severe cerebral arteriolosclerosis
(although frequently present), and/or the presence of other degenerative brain diseases, including [alpha]-synucleinopathies, and non-AD tauopathies, such as PART, progressive supranuclear palsy, and argyrophilic grain disease.
Of the 268 patients without macroinfarcts, 33 (7.9%) had microinfarcts, 62 (14.8%) had arteriolosclerosis
, and 24 (5.7%) had both microinfarcts and arteriolosclerosis
They include: vascular dementia (a term that encompasses dementia caused by blockages in the flow of blood to cells in the brain caused by a major stroke or a series of small, imperceptible strokes, or by small vessel disease); arteriolosclerosis
(a condition in which small cerebral vessels supplying the brain's white matter--communications networks among brain cells--become gradually impaired through factors such as high blood pressure, inflammation, thickening and narrowing of the blood vessels, or inadequate blood flow); and cerebral amyloid angiopathy (a condition characterized by the accumulation of deposits of amyloid protein in cerebral blood vessels, causing blood vessel narrowing and heightening the risk of stroke).
Mad cow disease, cancer, arteriolosclerosis
, mercury poisoning in fish, etc., have scared people into eating 'more vegetarian.'
One glomerulus showed severe hyaline arteriolosclerosis
with significant loss of the cellular element and matrix deposition.
Nagahama et al., "Brain arteriolosclerosis
and hemodynamic disturbance may induce leukoaraiosis," Neurology, vol.
It has previously been reported that the incidence rate of renal arteriolosclerosis
is positively correlated with the degree and duration of hypertension.12-15 In this study, Stage I and Stage II hypertensive patients were free from renal vascular changes and subject to moderate changes respectively, whereas Stage III ones suffered from severe renal arteriolosclerosis
, best scored on glomerular hilar arterioles, was typically medial hypertrophy with thickened layers of smooth muscle.
In 1953, Scheie classified the changes of hypertension and arteriolosclerosis
separately into five stages ranging from normal to the most severe changes in the retina (Table 1).
A moderate degree of diffuse arteriolosclerosis
is more pronounced in patients with diabetes than it is in patients with any other disease, except those associated with chronic transplant glomerulopathy.
In this system of classification, Scheie quantifies the changes of hypertension and arteriolosclerosis
separately, in a five-stage classification ranging from normal to the most severe changes visible in the retina.