arteriosclerosis

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Related to arteriosclerotic: arteriosclerosis, atherosclerosis

arteriosclerosis

(ärtĭr'ēōsklərō`sis), general term for a condition characterized by thickening, hardening, and loss of elasticity of the walls of the blood vessels. These changes are frequently accompanied by accumulations inside the vessel walls of lipids, e.g., cholesterol; this condition is frequently referred to as atherosclerosis. Initially lesions are formed on the arterial walls, which results in blistering and the accumulation of low-density cholesterol. This produces higher blood pressure, which facilitates the imbedding of cholesterol and calcium in the vessel walls. The fatty material accumulates calcium and produces hard plaques, thus hardening the walls of the vessels. As the vessel walls thicken, the passageways through the vessels narrow, decreasing the blood supply to the affected region. Constriction of the coronary arteries may affect the heart (see coronary artery diseasecoronary artery disease,
condition that results when the coronary arteries are narrowed or occluded, most commonly by atherosclerotic deposits of fibrous and fatty tissue. Coronary artery disease is the most common underlying cause of cardiovascular disability and death.
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, heart diseaseheart disease,
any of several abnormalities of the heart and its function in maintaining blood circulation. Heart disease is the cause of approximately half the deaths in the United States each year.
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). If the leg vessels are affected, there may be pain with walking and an onset of gangrene. When there is total clotting of a vessel (thrombosisthrombosis
, obstruction of an artery or vein by a blood clot (thrombus). Arterial thrombosis is generally more serious because the supply of oxygen and nutrition to an area of the body is halted.
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) the result may be a heart attack (if it occurs in the coronary arteries) or strokestroke,
destruction of brain tissue as a result of intracerebral hemorrhage or infarction caused by thrombosis (clotting) or embolus (obstruction in a blood vessel caused by clotted blood or other foreign matter circulating in the bloodstream); formerly called apoplexy.
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 (if in cerebral arteries).

Arteriosclerosis risk factors include hypertensionhypertension
or high blood pressure,
elevated blood pressure resulting from an increase in the amount of blood pumped by the heart or from increased resistance to the flow of blood through the small arterial blood vessels (arterioles).
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, elevated levels of fats in the blood, cigarette smoking, diabetes mellitus, and obesity. Genetic risks are related to the ability of the body to process (uptake and metabolize) low-density lipids that contain cholesterol. Reduction of body cholesterol to normal levels through cholesterol-lowering drugs and a restricted-fat diet is usually prescribed. The latter generally entails substitution of vegetable fats for animal fats, although the use of trans fats, artificially hydrogenated vegetable oils found in margarine and vegetable shortening, was linked to increased risk of coronary disease, and they have been banned or restricted in packaged foods in the United States and other nations. Treatment of hypertension, stress management, and cessation of smoking are also important. Increasing consumption of antioxidants and folic acid may be protective. Surgical treatment that bypasses clogged areas or procedures such as angioplastyangioplasty
, any surgical repair of a blood vessel, especially balloon angioplasty or percutaneous transluminal coronary angioplasty, a treatment of coronary artery disease.
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 are sometimes necessary; gene therapy that forces the growth of new blood vessels bypassing an area has also been used. Exercise often can increase utilization of excess low-density lipids. Although the relationship between blood cholesterol levels and arteriosclerosis is not fully understood, the utilization of low-density lipids appears to be a primary indicator of the risk of arteriosclerosis.

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arteriosclerosis

[är‚tir·ē·ō·sklə′rō·səs]
(medicine)
A degenerative arterial disease marked by hardening and thickening of the vessel walls.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.

arteriosclerosis

a pathological condition of the circulatory system characterized by thickening and loss of elasticity of the arterial walls
Collins Discovery Encyclopedia, 1st edition © HarperCollins Publishers 2005
References in periodicals archive ?
The results of this study provide some evidence that CRM may decrease the uniaxial tensile properties of rabbit arteriosclerotic ICA, but with no effect on normal group.
Miyata et al., "Long-term inhibition ofRho-kinase induces a regression of arteriosclerotic coronary lesions in a porcine model in vivo," Cardiovascular Research, vol.
(7) The Raynaud's phenomenon and pulmonary hypertension, in particular, and renal crisis caused by fibrotic arteriosclerotic changes may be observed due to vascular involvement.
The high correlation between the visceral fat volume and the development of arteriosclerotic diseases is well known [1-5].
Tanabe et al., "Plaque-like structures and arteriosclerotic changes in "diffuse neurofibrillary tangles with calcification" (DNTC)," Acta Neuropathologica, vol.
Patients with proximal femoral osteoporosis have been reported with reduced density of arterial capillaries and more frequent arteriosclerotic vascular lesions [31].
Arteriosclerotic lesions in pyridoxine-deficient monkeys.
The following findings were deemed clinically important but not needing acute change in management: (i) cerebral arteriosclerotic changes; (ii) sub-acute and chronic ischaemic changes (>48 hours); (iii) asymptomatic aneurysm; and (iv) asymptomatic congenital variant or abnormality.
In the meantime, based on the current results, the authors hypothesize that higher diastolic blood pressure may speed up arteriosclerotic changes in the brain-or the loss of elasticity and thickening of arterial walls that causes decreased blood circulation, and as a result, can lead to cognitive impairment.
It doesn't make sense to treat a number especially in the absence of any arteriosclerotic disease.
Arteriosclerotic changes (described as silver or copper wiring of arterioles) result in a breakdown of the blood-retinal barrier, resulting in exudation of blood (haemorrhages), lipids (hard exudates), and subsequent ischaemia of nerve-fibre layers (cotton-wool spots).