artificial chromosome


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Related to artificial chromosome: Bacterial artificial chromosome

artificial chromosome

[‚ärd·ə¦fish·əl ′krō·mə‚sōm]
(genetics)
A functional chromosome constructed by genetic engineering, having a centromere (and a telomere at each end, if linear rather than circular) and thus transmissable in cell division after introduction into a cell.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
"In theory, an artificial chromosome would be a great advance because it wouldn't integrate but it would replicate and segregate," says Melissa A.
Comparative sequence analysis of colinear barley and rice bacterial artificial chromosomes. Plant Physiol.
Reason: What do you think about artificial chromosomes? Are we going to have those soon?
Abbreviations: AFLP, amplified restriction fragment length polymorphism; BAC, bacterial artificial chromosome; bp, base pairs; CUGI, Clemson University Genomics Institute; EST, expressed sequence tag; kb, kilobases; LOD, logarithm of odds; NBS, nucleotide binding sites; NLS, nuclear localization signal; LRR, leucine rich repeats; PCR, polymerase chain reaction; RFLP, restriction fragment length polymorphism; RGP, Rice Genome Research Program; SSR, simple sequence repeat; STS, sequence tagged site; Xoo, Xanthomonas oryzae pv.
Bacterial artificial chromosome libraries have also been used to develop physical maps for genomic regions containing resistance gene analog sequences (Marek and Shoemaker, 1997).
The global multiplexed molecular diagnostics market segmentation is based on technology (low density multiplexed assays, microplate assays, quantitative PCR, medium density multiplexed assays, antibody arrays, bead-based arrays, mass spectrometry, reverse arrays, high density multiplexed assays, bacterial artificial chromosome arrays, protein arrays, very high density multiplexed assays, oligonucleotide arrays, phage display, next generation sequencing assays), and applications (allergies, autoimmune diseases, cardiac disorders, infectious disease diagnosis, oncology).
Initialize Genetic algorithms (GA) proposed by[9],which begin with an initial population consisting of individual chromosomes(a set of solutions),where each individual contains a phenotype (job sequence for each machine) and a genotype (machine schedule) artificial chromosome. The chromosome is represented by using job-based representation, where a chromosome is symbolized by a binary string, and each bit stands for the order of a job pair (u,v) for a particular machine m.
Bacterial artificial chromosome library screening: The buffalo BAC library (Stafuzza et al.
Refined human artificial chromosome vectors for gene therapy and animal transgenesis.
The researchers created the artificial chromosome by assembling synthetic strands of DNA together, which were incorporated into the genome of a multi-celled organism, like yeast.
Researchers were able to create a human artificial chromosome in the lab from chemical building blocks, the Independent reported.
Objective: The aim of this study was to determine the efficiency of the high throughput FISH analysis (HTFA) method for detecting genetic alterations in hematological malignancies, which is a new bacterial artificial chromosome array-based approach.