asparagine


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Related to asparagine: aspartic acid

asparagine

(əspâr`əjēn), organic compound, one of the 20 amino acidsamino acid
, any one of a class of simple organic compounds containing carbon, hydrogen, oxygen, nitrogen, and in certain cases sulfur. These compounds are the building blocks of proteins.
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 commonly found in animal proteins. Only the l-stereoisomer participates in the biosynthesis of mammalian proteins. Its structure is identical to that of the amino acid aspartic acidaspartic acid
, organic compound, one of the 20 amino acids commonly found in animal proteins. Only the l-stereoisomer participates in the biosynthesis of proteins.
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, except that the latter compound's acidic side-chain carboxyl group has been coupled with ammonia, yielding an amide. Like glutamineglutamine
, organic compound, one of the 20 amino acids commonly found in animal proteins. Only the l-stereoisomer occurs in mammalian protein.
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, asparagine is important in the metabolism of toxic ammonia in the body. The relatively unreactive, neutral amide group in the side chain of asparagine confers no special properties upon this amino acid once it is included within a protein by two peptide bonds. Asparagine is not essential to the human diet, since it can be synthesized from aspartic acid. The first amino acid to be isolated from its natural source, asparagine was purified from asparagus juice in 1806; proof of the occurrence of this amino acid in proteins was finally obtained in 1932.

asparagine

[ə′spar·ə‚jēn]
(biochemistry)
C4H8N2O3 A white, crystalline amino acid found in many plant seeds.
References in periodicals archive ?
It can be seen in Table 5 that in cells grown in MA medium, the most significant decreases in the inhibition of the phenylalanine uptake were observed with trifluoroleucine in the Y294[DELTA]bap2[DELTA]gap1 strain and with asparagine in the Y294[DELTA]agp1[DELTA]gap1 strain.
The candidates, serine, threonine, arginine, asparagine, lysine, histidine, tyrosine, glutamine, and cysteine as well as glycine, as a negative control, were analyzed.
However, no comparable measurements of asparagine or glutamine have been taken.
Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family.
We measured the fluorescence intensity of all 20 protein amino acids; in descending order of intensity, with percentage fluorescence compared to that of tyrosine, they were tyrosine (100%), phenylalanine (88%), arginine (77.5%), methionine (70.8%), lysine (66.3%), glutamine (61.5%), histidine (51.4%), threonine (50.6%), isoleucine (45.4%), valine (36.9%), leucine (30.7%), asparagine (28.2%), glutamate (22.5%), glycine (22.1%), cysteine (15.2%), serine (13.0%), tryptophan (4.1%), alanine (3.7%), and aspartate (3.2%).
Vauquelin had obtained asparagine (see 1806), and Wollaston (see 1800) had obtained cystine (from the Greek word for "bladder") from a bladder stone.
Likewise, serine (2.55 ug/mL), asparagine (7.64 ug/mL), alanine (0.39 ug/mL), aspartic acid (0.35ug/mL), threonine (0.20ug/mL), glutamine (0.92ug/mL), proline (0.32 ug/mL) and phenyl alanine (0.16ug/mL) were detected in Berkut under normal condition only, and under both normal and stress in Krichauff.
Asparagine can be synthesized from aspartate and glutamine (or ammonia) by asparagine synthetase in mammals [5,6].
As can be seen, the most important metabolite markers for the Alzheimer group included alanine, glutamine, serine, valine, isobutyrate, carnitine, taurine, pantothenate, glucose, asparagine, succinate, glycine, creatinine, isoleucine, pyruvate, betaine, choline, scyllo-inositol and myo-inositol.
Asparagine endopeptidase cleaves AaAaAeAA[+ or -]-synuclein and mediates pathologic activities in Parkinson's (http://www.medicaldaily.com/link-between-parkinsons-and-alzheimers-diseases-may-lead-new-parkinsons-419730 disease . Nature Structural and Molecular Biology. 2017
Asparagine synthetase (ASNS) is an expression status present in various tumour types, such as leukaemia, lymphoma and pancreatic cancer.

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