The present descriptive comparative study revealed significantly lower aspartate aminotransferase
and alanine aminotransferase levels in haemodialysed CKD patients compared to both healthy controls and pre-dialysed CKD patients.
Multiple linear regression analysis was used with serum bilirubin as an objective variable and age, sex, disease duration, medication history, diabetes mellitus, hypertension, alanine aminotransferase, aspartate aminotransferase
, TP, CRP, and ESR as explanatory variables, indicating that serum bilirubin was correlated with ESR (b = -0.170, P < .001) independently of other parameters in multiple linear regression analysis (Table 3).
HCV: hepatitis C virus; AST: aspartate aminotransferase
; ALT: alanine aminotransferase; AAR: aspartate aminotransferase
to alanine aminotransferase ratio; PT: prothrombin time; INR: international normalized ratio; RDW: red cell distribution width; APRI: aspartate aminotransferase-to-platelet ratio index; FIB-4: fibrosis index based on the 4 factors; RPR: red cell distribution width to platelet ratio; PLR: platelet-lymphocyte ratio.
Table 1 : Trend of liver function tests Investigation Day 1 Day 2 Day 3 Day 4 (Post Surgery) Serum bilirubin 7.08 mg/dL 6.23 5.73 2.37 Conjugated bilirubin 6.52 mg/dL 5.06 4.48 4.87 AST 1830 IU/L 2630 1290 370 ALT 2510 IU/L 1900 1260 930 INR 1.2 1.2 1.0 1.0 Investigation Day 6 Day 8 Day 10 Serum bilirubin 8.57 8.32 5.4 Conjugated bilirubin 7.00 7.01 4.3 AST 180 180 120 ALT 340 270 160 INR 1.0 AST, Aspartate aminotransferase
; ALT, alanine aminotransferase, INR, International Normalization Ratio.
Plasma enzyme activities of alanine aminotransferase and aspartate aminotransferase
were determined using commercial kits (Zhongsheng Bio-Technology and Science Inc., Beijing, China) on a random access analyzer (Technicon RA 1000, Tarrytown, NY, USA).
The increase in the kidney aspartate aminotransferase
activity as the concentrations of the plant leaf dust increased may be attributed to the potency of the plant leaf dust; as the enzyme is specific in kidney function (Witthawaskul et al., 2003).
Table I.- Effect of acute doses of cypermethrin administered at 7.5 g/L for 9 days on the activities (MeanSD) of glutamate dehydrodegase (GDH M formozan/mg protein/h) aspartate aminotransferase
(ASAT M oxaloacetate/mg protein/h) and alanine aminotransferase (ALAT M pyruvate/mg protein/h) of gill muscles and liver of a freshwater fish Cyprinus carpio.
The aspartate aminotransferase
to platelet ratio index before treatment was 1.61 +- 1.00 and after treatment 1.10 +- 1.08.
No pattern between years, sexes, or ages was apparent for plasma aspartate aminotransferase
, calcium, creatine kinase, lactate dehydrogenase, total protein, and triglycerides (Table 1).
increase in crevicular fluid during experimental periodontitis in beagle dogs.
Serum total cholesterol, triglycerides, alanine aminotransferase (ALT) and aspartate aminotransferase
(AST) levels were determined.
Levels of aspartate aminotransferase
( AST) 54 to 60 per cent higher than the controls, indicting damage to the liver or heart