aspidospermine


Also found in: Medical.

aspidospermine

[¦as·pə‚dō′spər‚mēn]
(pharmacology)
C22H30O2N2 White to brownish-yellow crystals with a melting point of 132-136°C; soluble in water, alcohol, chloroform, and ether; used in medicine.
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As some alkaloids are known to have modulating effects on chloroquine activity (Frappier et al., 1996), we have tested two of the most active ones, N-formyl aspidospermidine 3 and aspidospermine 5, in association with chloroquine, in order to determine the existence of a possible cumulative effect between these molecules.
The demethylation of aspidospermine was performed according to a method described by Janot and Goutarel, 1957.
Therefore, we have prepared by demethylation of aspidospermine 5 the compound 6 possessing a phenolic fonction and a free ethyl chain.