Surgical excision revealed a cellular glial neoplasm with numerous astrocytic
and oligodendroglial-appearing cells displaying scattered mitotic figures.
where they found in vivo that tumor cells lose the expression of the tumor suppressor protein phosphatase and tensin homolog (PTEN) after incorporating astrocytic
exosomes, due to the presence of a microRNA (miRNA) that targets PTEN .
(b) Immunofluorescence staining showed positive expression of the neuronal markers MAP2, tau, and [beta]-tubulin III in the control and ANDRO groups, but weakly positive expression of the astrocytic
This type of astrocytic
response is observed in all our model systems of transmissible prion disease, but is absent from the nontransmissible forms of PrP (i.e., amyloid plaques in absence of clinical disease), suggesting that this single mouse may represent a transmission of infection rather than a consequence of seeding of inoculum (25,28).
Conti et al., "Powerful anticonvulsant action of IL-1 receptor antagonist on intracerebral injection and astrocytic
overexpression in mice," Proceedings of the National Academy of Sciences of the United States of America, vol.
The diameter of the astrocytic
soma was estimated as: d = (a+b)/2 (a and b were the longitudinal and transversal diameters of an astrocyte respectively).
oxidative stress and nutrient depletion) can elicit and/or enhance the neuroprotective effects of astrocytes through the activation of astrocytic
signaling and alteration of astroglial function.
Chapter authors, who work in neurological surgery, neuroscience, human genetics, biology, and other medical fields in the US, Europe, China, and Brazil, address their therapeutic use in central nervous system injuries, genetic disease, and Duchenne muscular dystrophy, and gene regulation by natural antisense transcripts, silencing gene expression by employing transcription factor decoy strategies, and genetic alterations of astrocytic
tumors and gene therapy for treatment of gliomas.
The main target for the antibodies by IIF is the astrocytic
foot processes that abut the abluminal surface of capillaries in the brain; they also bind along the subpial layer and at the glia limitans.
A second possible explanation for the decrease in CNTF-ir is that in response to physiological activation the SON undergoes a morphological change that decreases the area the VGL occupies and the orientation of the astrocytic
processes (3); therefore, immuno-electron microscopy will be employed to elucidate if CNTF expression decreases as a result of the morphological change that occurs in the SON.
There were no hemorrhages and no discernible glial reaction, astrocytic
or microglial, adjacent to changed neurons.
A massive proliferation of fibrous astrocytic
processes accompanied by reactive microglia (figure 4, A)--many of which displayed a phagocytic role (figure 4, B)--and amyloid bodies occupied regions of the nerves that were characterized by an absence of axons.