Human iPSC-derived immature
astroglia promote oligodendrogenesis by increasing TIMP-1 secretion.
Munch, "Activated
astroglia during chronic inflammation in Alzheimer's disease--do they neglect their neurosupportive roles?" Mutation Research--Fundamental and Molecular Mechanisms of Mutagenesis, vol.
Raju, "Exposure to CSF from sporadic amyotrophic lateral sclerosis patients induces morphological transformation of
astroglia and enhances GFAP and S100beta expression," Neuroscience Letters, vol.
Experimental autoimmune panencephalitis and uveoretinitis transferred to the Lewis rat by T lymphocytes specific for the S100 beta molecule, a calcium binding protein of
astroglia. J Exp Med 1994;180:817-29.
Dehydroepiandrosterone, pregnenolone and sex steroids down-regulate reactive
astroglia in the male rat brain after a penetrating brain injury.
IL action on blood-brain barrier may induce the expression of other inflammatory mediators produced by microglia and
astroglia. For instance, the lack of IL-1R1 specifically in endothelial cells precluded the brain increase of IL-1[beta], TNF-[alpha], and IL-6 in stressed rats despite the presence of reactive microglia [59, 60], which places IL-1[beta] and its receptor on endothelial cells as central mediators of brain inflammatory responses.
The technique gives researchers a tool to look at diseased human brain cells, including specialized nerve cells called
astroglia, which play a critical role in ALS progression.
Astroglia as metal depots: molecular mechanisms for metal accumulation, storage and release.
Staykova et al., "Evaluation of [[sup.123]I]CLINDE as a potent SPECT radiotracer to assess the degree of
astroglia activation in cuprizone-induced neuroinflammation," European Journal of Nuclear Medicine and Molecular Imaging, vol.
Cells called
astroglia help regulate blood flow, provide energy to nearby cells and even influence message movement between nerve cells.
It is also known that alcohol induces an early transformation of radial
astroglia into astrocytes, which leads to an impaired migration of neurons within the brain (Miller and Robertson, 1993).