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atrophy (ătˈrəfē), diminution in the size of a cell, tissue, or organ from its fully developed normal size. Temporary atrophy may occur in muscles that are not used, as when a limb is encased in a plaster cast. Interference with cellular nutrition, as through starvation; diseases affecting the nerve supply of tissues, e.g., poliomyelitis and muscular dystrophy; and prolonged disuse may cause a permanent wasting away of tissue. Atrophy may also follow hypertrophy.
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The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.



the decrease in the size of an organ or tissue of the living organism of animals and man, accompanied by a disorder or cessation of functions. Atrophy is the result of a predominance of dissimilation over the processes of assimilation.

Atrophy can be physiological and pathological, systemic and local. Physiological atrophy is a function of the growth changes of an organism (atrophy of the thymus during puberty, atrophy of the sex glands, skin, and bones in old people, and so on). General pathological atrophy (emaciation, cachexia) appears in cases of insufficient nutrition, chronic infection or intoxication, or disorders of the endocrine glands or of the central nervous system. Local pathological atrophy arises from various causes—from a disorder in the regulation of the trophic nerves (for example, atrophy of the skeletal muscles during poliomyelitis), from insufficient supply of blood (for example, atrophy of the brain cortex during atherosclerosis of the blood vessels of the brain); dysfunctional atrophy (for example, atrophy of the optic nerve after removal of an eye), as a result of pressure (for example, atrophy of the kidney in cases of embolism of the urether and accumulation of urine in the renal pelvis), from lack of use (for example, atrophy of the muscles in the extremities after long immobilization), or from the effects of physiological and chemical factors (for example, atrophy of the lymphoid tissue from the effects of solar energy, atrophy of the thyroid gland upon application of iodine preparations).

When an organ atrophies it diminishes in size but subsequently sometimes appears larger as a result of the expansion of fat tissue which replaces the atrophied cellular elements. Pathological atrophy is, up to a certain stage, a reversible process. Treatment consists of the elimination of the causes producing atrophy.


Strukov, A. I. Patologicheskaia anatomiia. Moscow, 1967.
Cameron, G. R. Pathology of the Cell. Edinburgh, 1952.


The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.


Diminution in the size of a cell, tissue, or organ that was once fully developed and of normal size.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.


a wasting away of an organ or part, or a failure to grow to normal size as the result of disease, faulty nutrition, etc.
Collins Discovery Encyclopedia, 1st edition © HarperCollins Publishers 2005
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Based on a pedigree assembled by Qu et al.4 atrophia maculosa varioliformis cutis has autosomal dominant inheritance.
Treatment for atrophia maculosa varioliformis cutis has not been discussed in the literature.
To the best of our knowledge, only few cases of atrophia maculosa varioliformis cutis have been described in world's literature.
(54.) On "craving" and cachexia Africana, see Carpenter, "Observations" 149; Imray, "Observations" 313; and Mason, "On Atrophia a Ventriculo" 292.
Oral submucous fibrosis (OSMF) is a chronic, progressive, scarring, high risk precancerous condition of oral mucosa seen primarily in Indian subcontinent, southeast Asia, Taiwan, southeast China and Papua New Guinea.1 It was first described by Schwartz (1952) as he found this condition of oral mucosa including palate and pillars of oropharynx first in five Kenyan women named this as "Atrophia Idiopathica Tropica Mucosae Oris".
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