The key application of KREX is the discovery of autoantibody
biomarkers for two core medical use cases.
The three ZNT8 autoantibody
variants together improve the diagnostic sensitivity of childhood and adolescent type 1 diabetes.
In Vermeersch P et al.'s article (1), the anti-centriole pattern was the rarest autoantibody
"We are very excited to advance our autoantibody
into the clinic with Servier," said professor Adrian Hayday, co-founder of ImmunoQure.
levels were measured by qualitative immunoprecipitation assay.
Alternatively, autoantibodies may be generated through the initial damage to myocardial cells by viral infection that releases a large quantity of self-antigens into the circulation, in which case the viral infection is followed by a second phase of immune process of the disease, recruiting active immunocompetent cells into the cardiac tissue that favor B cell activation and subsequent autoantibody
production, resulting in myocardium damage and progression of heart disease [89-115].
The anti-lgE/anti-FcepsilonRlalpha autoantibody
network in allergic and autoimmune diseases.
CA-I and CA-II autoantibody
levels were measured in serum samples obtained from each of the three groups and compared statistically.
Among the anti-ENA autoantibody
subtypes, anti-ACA was seen in 37% of patients, anti-Scl-70 in 24%, anti-RNP in 9%, and anti-RNAPIII in 5%; other subtypes were rarer.
This study then presents a new model for circulating troponins based on this in-depth evaluation of this interfering autoantibody
Furthermore, plasma IgA autoantibody
levels binding to oxLDL have been shown to be positively and IgG autoantibody
levels to be negatively associated with markers of glucose metabolism and also to be independent risk factors for type 2 diabetes .
Since evidences show that protein overexpression could induce humoral responses in cancer patients  and Ezrin proteins were found to be upregulated in ESCC (including early-stage ESCC) in comparison to adjacent normal tissue in our previous study , it is plausible that Ezrin might induce autoantibody
production in ESCC patients.