The key application of KREX is the discovery of
autoantibody biomarkers for two core medical use cases.
The three ZNT8
autoantibody variants together improve the diagnostic sensitivity of childhood and adolescent type 1 diabetes.
In Vermeersch P et al.'s article (1), the anti-centriole pattern was the rarest
autoantibody pattern.
"We are very excited to advance our
autoantibody into the clinic with Servier," said professor Adrian Hayday, co-founder of ImmunoQure.
Anti-MDA5
autoantibody levels were measured by qualitative immunoprecipitation assay.
Alternatively, autoantibodies may be generated through the initial damage to myocardial cells by viral infection that releases a large quantity of self-antigens into the circulation, in which case the viral infection is followed by a second phase of immune process of the disease, recruiting active immunocompetent cells into the cardiac tissue that favor B cell activation and subsequent
autoantibody production, resulting in myocardium damage and progression of heart disease [89-115].
The anti-lgE/anti-FcepsilonRlalpha
autoantibody network in allergic and autoimmune diseases.
CA-I and CA-II
autoantibody levels were measured in serum samples obtained from each of the three groups and compared statistically.
Among the anti-ENA
autoantibody subtypes, anti-ACA was seen in 37% of patients, anti-Scl-70 in 24%, anti-RNP in 9%, and anti-RNAPIII in 5%; other subtypes were rarer.
This study then presents a new model for circulating troponins based on this in-depth evaluation of this interfering
autoantibody.
Furthermore, plasma IgA
autoantibody levels binding to oxLDL have been shown to be positively and IgG
autoantibody levels to be negatively associated with markers of glucose metabolism and also to be independent risk factors for type 2 diabetes [8].
Since evidences show that protein overexpression could induce humoral responses in cancer patients [19] and Ezrin proteins were found to be upregulated in ESCC (including early-stage ESCC) in comparison to adjacent normal tissue in our previous study [17], it is plausible that Ezrin might induce
autoantibody production in ESCC patients.