G proteins and autocrine signaling
differentially regulate gonadotropin subunit expression in pituitary gonadotrope.
Neoplastic EVs exert oncogenic functions that (1) boost malignancy through autocrine signaling
, (2) induce a suppression of HSPC functions and SC malignant transformation, (3) modify the BM environment in favor of cancer/leukemic cells acting also on MSCs.
Due to the involvement of EGFR/ADAM17 paracrine and autocrine signaling
in several lung disorders [109, 116], modulation of ADAM17 and EGFR activation in both COPD and CF is important, to keep the balance between anti-inflammatory processes and promotion of inflammation, and also between regeneration and excessive tissue remodeling.
The vasoconstrictor response initiated by a1-adrenoceptor activation in arterioles appears to be very complex and also involves autocrine signaling
mediated by ATP release through pannexin channels.
Many cytokines upregulated in cancer cells are mediated through autocrine signaling
. Meanwhile, cancer cells also use paracrine-signaling mechanism to recruit immune cells to the tumor site.
Sun, "PKCa take part in CCR7/NF-[kappa]B autocrine signaling
loop in CCR7-positive squamous cell carcinoma of head and neck," Molecular and Cellular Biochemistry, vol.
Fassan et al., "An angiopoietin-like protein 2 autocrine signaling
promotes EMT during pancreatic ductal carcinogenesis," Oncotarget, vol.
Resistance mechanisms include constitutive autocrine signaling
through EGFR or loss of the full-length BRAF V600E protein.
Because autocrine signaling
is not completely ruled out even in dissociated cells, it is possible that autocrine signaling
works differently between embryos of these two animals.
Because TGF-[beta] is widely regarded as the central progenitor of fibrotic scars and has a large capacity for autocrine signaling
, the degradation of Sp1 may serve as a putative pharmacological target in keloids.
It is now clear that tumor cells acquire a certain degree of self-sufficiency through autocrine signaling
pathways that facilitate their growth, survival, and invasion .
Citation: "Autocrine Signaling
Based Selection of Combinatorial Antibodies That Transdifferentiate Human Stem Cells"; Lerner et a!.; early edition of the Proceedings of the National Academy of Sciences, 22 April 2013, DOI: 10.1073/pnas.1306263110