autoimmune disease


Also found in: Dictionary, Thesaurus, Medical.

autoimmune disease,

any of a number of abnormal conditions caused when the body produces antibodiesantibody,
protein produced by the immune system (see immunity) in response to the presence in the body of antigens: foreign proteins or polysaccharides such as bacteria, bacterial toxins, viruses, or other cells or proteins.
..... Click the link for more information.
 to its own substances. In rheumatoid arthritisarthritis,
painful inflammation of a joint or joints of the body, usually producing heat and redness. There are many kinds of arthritis. In its various forms, arthritis disables more people than any other chronic disorder.
..... Click the link for more information.
, a group of antibody molecules called collectively RF, or rheumatoid factor, is complexed to the individual's own gamma globulin blood proteins; the circulating complex apparently causes tissue inflammation and muscle and bone deformities. In Hashimoto's thyroiditis, an inflammatory disease of the thyroid gland, antibodies are produced against the thyroid protein thyroglobulin. In some blood disorders, antibodies may be produced against the body's own red and white blood cells. Myasthenia gravis, a disease characterized by weakened muscles, is thought to have an autoimmune origin. In systemic lupus erythematosus it has been shown that individuals have antibodies to certain of their own body substances that for some reason are acting as antigens; these substances include the individual's own nucleic acids and cell organelles such as ribosomes and mitochondria. Lupus can cause dysfunction of many organs, including the heart, kidneys, and joints. Because lupus and certain diseases of probable autoimmune origin, e.g., scleroderma and dermatomyositis, affect collagencollagen
, any of a group of proteins found in skin, ligaments, tendons, bone and cartilage, and other connective tissue. Cells called fibroblasts form the various fibers in connective tissue in the body.
..... Click the link for more information.
 (connective tissue) throughout the body and blood vessels, they are referred to as collagen-vascular diseases. In rheumatic fever, the individual produces antibodies to antigens of streptococcal bacteria; it is believed that the streptococcal antigens are structurally similar to antigens of the heart and that antistreptococcal antibodies, combining with antigenic sites on the heart, damage the muscle and heart valves. Diseases of the immune system are currently treated by a variety of nonspecific immunosuppressive drugsimmunosuppressive drug,
any of a variety of substances used to prevent production of antibodies. They are commonly used to prevent rejection by a recipient's body of an organ transplanted from a donor.
..... Click the link for more information.
 and steroidssteroids,
class of lipids having a particular molecular ring structure called the cyclopentanoperhydro-phenanthrene ring system. Steroids differ from one another in the structure of various side chains and additional rings. Steroids are common in both plants and animals.
..... Click the link for more information.
.

autoimmune disease

[¦ȯd·ō·ə′myün di‚zēz]
(immunology)
An illness involving the formation of autoantibodies which appear to cause pathological damage to the host.
References in periodicals archive ?
The autoimmune disease therapeutics market is anticipated to experience significant market growth during the forecast period due to early diagnosis of the disease, the latest launch of advanced therapy, and increased incidence of autoimmune disease.
"Our laboratory is studying males and females who get autoimmune disease to identify hints that might explain why females are so much more likely to get many autoimmune diseases, especially in the case of lupus, in which nine times more women than men get the disease."
Alternatively, vaccines for autoimmune diseases need to be therapeutic and focused on cellular immunity, not antibodies.
Polyautoimmunity is the coexistence of two or more autoimmune diseases in an individual, and if there are three or more autoimmune diseases, it is called Multiple Autoimmune Syndrome (MAS), of which vitiligo is often a component.
The hypothesis postulates that a decline in exposure to certain micro-organisms is likely to increase chances of developing autoimmune diseases. Autoimmune diseases (AD) refer to a group of diseases caused by the attack of body tissues by the immune system.
Keywords: Autoimmune disease, Dry eye, Impression cell, Apoptosis.
Autoimmune diseases occur when the immune system, which is meant to defend your body, actually attacks it.
One particularly aggrieved fan condemned Lorde's "ignorant analogy," especially in light of fellow singer Selena Gomez's public battle with lupus - which means that she is, in fact, a friend of Lorde's with an autoimmune disease.
The 'Green Light' star has come under fire after comparing her friend Taylor Swift to an "autoimmune disease" in an interview with The Guardian on Saturday.
The researchers matched 59,627 patients who received the herpes zoster vaccine with 119,254 unvaccinated patients, based on age, sex, race, calendar year, autoimmune disease type, and use of autoimmune drugs (biologies, disease-modifying antirheumatic drugs, and glucocorticoids).
Autoimmune diseases are characterized by a multifactorial aetiology, in which genetic factors interplay with environmental factors.
The question of why the immune system in some people attacks healthy cells remains top of mind for biopharmaceutical researchers striving to discover new treatments and cures for the 23.5 million Americans affected by an autoimmune disease, comments Stephen Ubl, president and chief executive officer of PhRMA.