When the gut microbe Enterococcus gallinarum leaks out of the intestines and sets up camp in other organs such as the liver, it appears to trigger an autoimmune response
similar to what's seen in lupus, a new study in mice reveals.
The conditions "may be linked through a common autoimmune response
from exposed intracellular or altered cell surface antigens on damaged melanocytes," the investigators said.
Thus, they suggest that at least k chains can be considered a very sensitive circulating biomarker of B cell activation and humoral autoimmune response
. This may represent a preliminary important study for a more detailed multicenter analysis.
"We are now in a position to precisely define the viral factors responsible for the induction of the autoimmune response
Therefore, an alteration in the balance of these subgroups can trigger an autoimmune response
The etiology of PUK has not been completely ascertained, but consensus has centered on an autoimmune response
to a localized antigen.
Certain triggers, such as oxidative stress or physical trauma, expose antigens and lead to an autoimmune response
People with celiac disease have higher than normal levels of certain autoantibodies that trigger the autoimmune response
This could be due to increased permeability of the intestine, raising the level of antigen exposure, resulting in increased risk of an autoimmune response
to brain components or it may be that gluten proteins are broken down into psychoactive peptides.
When the body's inflammatory response is functioning normally, it protects and repairs tissue; when stress on the joints or an autoimmune response
causes inflammation, it functions in an out-of-control manner that can harm more than it heals.
You experience an autoimmune response
, in which your immune system attacks the undigested gluten proteins, and the lining of your small intestine becomes inflamed and damaged.
If this barrier function is weakened, the adaptive immune processes initiated in the gut may be released into the systemic system, triggering an allergic or autoimmune response
and symptoms in the host (McCance, Huether, Brashers, & Rote, 2010).