These findings provide important biological insights into the autoimmune response
in lupus that could lead to the identification of novel drug targets and therapeutic approaches to treat SLE.
Th1 cells predominantly produce Interleukin-2 (IL-2), interferon-[gamma] (IFN-[gamma]), and tumor necrosis factor-[beta] (TNF-[beta]), which mediate autoimmune pathology, while Th2 cells mainly release IL-4, and IL-10, leading to a dominant protective effect against autoimmune responses
Molecular mimicry-based on a structural similarity between a pathogen or metabolite and self structures, evoking an immune response against the foreign particles but also an autoimmune response
against the self molecules they resemble.
When the body's inflammatory response is functioning normally, it protects and repairs tissue; when stress on the joints or an autoimmune response
causes inflammation, it functions in an out-of-control manner that can harm more than it heals.
If this barrier function is weakened, the adaptive immune processes initiated in the gut may be released into the systemic system, triggering an allergic or autoimmune response
and symptoms in the host (McCance, Huether, Brashers, & Rote, 2010).
You experience an autoimmune response
, in which your immune system attacks the undigested gluten proteins, and the lining of your small intestine becomes inflamed and damaged.
The major indication for a gluten-free diet is celiac disease, an inflammatory disorder of the small intestine resulting from an inappropriate T-cell-mediated autoimmune response
to the ingestion of gluten by people who are genetically predisposed.
In rare cases (less than 1 percent) the Lyme vaccine causes an autoimmune response
resulting in kidney disease; retrievers are among the more susceptible breeds.
The researchers have now revealed how giving fragments of the proteins that are normally the target for the attack (antigens), leads to correction of the autoimmune response
These clues lead us to think that the first event in the formation of a new lesion is triggered by an environmental factor, rather than an autoimmune response
, after which the classic autoimmune response
develops," suggests Dr.
copri in the intestinal microbiota exacerbates colonic inflammation in mouse models and may offer insight into the systemic autoimmune response
seen in rheumatoid arthritis.
Coeliac disease occurs when gluten leads to an autoimmune response
that damages the lining of the small intestine.