autophagic vacuole


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Related to autophagic vacuole: heterophagy

autophagic vacuole

[¦ȯd·ō¦fā·jik ′vak·yə·wōl]
(cell and molecular biology)
A membrane-bound cellular organelle that engulfs pieces of the substance of the cell itself. Also known as autolysosome.
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In all cases, electron micrographs were reviewed for evidence of tubulofilamentous inclusions, autophagic vacuoles, and mitochondrial defects.
Rimmed or autophagic vacuoles were identified in all cases and were best highlighted on the Gomori trichrome stain (Figure 1).
Parasites incubated in the presence of compound (3) showed ultrastructural changes, such as the appearance of mitochondrial swelling with a reduction in the density of the mitochondrial matrix and the presence of vesicles inside the mitochondrion, indicating damage and significant change in this organelle; abnormal chromatin condensation, alterations in the nuclear envelope, intense atypical cytoplasmic vacuolization, and the appearance of autophagic vacuoles were also observed.
Likewise, granular cell tumors may arise in relation to the pituitary gland/stalk; however, these tumors owe their cytoplasmic granularity to numerous autophagic vacuoles, not mitochondria.
Type II programmed cell death or autophagic cell death involves the accumulation of autophagic vacuoles (AV) in the cytoplasm of dying cells as well as enlargement of the mitochondrial mass.