autophagy


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autophagy

[′ȯd·ə‚fā·jē]
(cell and molecular biology)
The cellular process of self-digestion.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
(NASDAQ: DCPH) has added a new candidate to its pipeline, DCC-3116, a potential first-in-class small molecule designed to inhibit cancer autophagy, a key tumor survival mechanism, the company said.
Numerous studies in humans and rodents have shown that autophagy is activated in catabolic disease conditions such as cancer [6], and that excessive activation of autophagy leads to muscle wasting and atrophy [7-9].
However, how curcumin relieves the IBD state through acting on autophagy has not been described yet until now, although curcumin was reported to promote autophagy by inhibiting the growth of several common tumors (12-14).
Cell hemostasis is maintained by autophagy through a correct disposal of damaged cellular and organelles (Green and Levine, 2014).
Salk Institute scientists studying the relationship of telomeres to cancer made a surprising discovery: a cellular recycling process called autophagy -- generally thought of as a survival mechanism -- actually promotes the death of cells, thereby preventing cancer initiation.
Sudden elevation of reactive oxygen species (ROS) induces the mitochondrial permeability transition pore (mPTP) opening and mitochondrial polarization, which determines the fate of the cell.[2],[3],[4],[5],[6],[7],[8] Minor injuries lead to decreases in the mitochondrial membrane potential and mPTP opening, which subsequently causes mitochondrial autophagy. Mitochondrial autophagy not only selectively removes impaired mitochondria but also prevents the production of ROS by damaged mitochondria.
"We found that cell metabolism significantly influences the ability to begin autophagy," says lead investigator Carol Mercer, an associate professor in the Division of Haematology and Oncology at the University of Cincinnati in Ohio.
Beclin-positive cells, which indicate the presence of autophagy, were distinguished by their dark-brown-stained cytoplasms 24 hours after burn injury in the zone of stasis and especially in the deep dermis.
Washington D.C [USA] Aug 29( ANI ): Researchers have discovered that cell metabolism plays an important role in the ability of cells to start a survival program called autophagy, an unwanted side effect of some anti-cancer drugs that help some tumor cells dodge treatment and eventually regrow into new tumours.
Autophagy is a mechanism of lysosomal degradation by which the cell destroys damaged organelles and microorganisms and helps to recycle macromolecules.
To achieve this goal, we revealed the role of ANDRO from three aspects: cell apoptosis, autophagy, and S100B expression.
Autophagy is a type of cell death process by which cells recycle their unessential organelles and components under stress conditions (9).