autophagy


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autophagy

[′ȯd·ə‚fā·jē]
(cell and molecular biology)
The cellular process of self-digestion.
References in periodicals archive ?
2] Recent reports suggest that autophagy can play an important role in tumor cell survival or death under metabolic stress conditions including hypoxia and anticancer treatment.
15] It has recently been shown that UVRAG, a component of the PI3KC3 complex, binding to Beclin1 component via its central conserved domain to stabilize the Beclin1-PI3KC3 complex, could induce autophagy.
According to the researchers, the next step will be to study the precise mechanisms underlying how autophagy in cells lining blood vessels contributes to improved blood vessel function.
After four weeks of RF-EMF exposure, evidence indicated that the autophagy pathway in the mice's cerebral cortex, but not the brainstem, was activated.
Further, the researchers shut down the genes responsible for autophagy and found that the worms lived longer, although crippled, lives.
This process, called autophagy, is what cells use to recycle their trash.
Brain cells from mice fed diets enriched with extra-virgin olive oil had higher levels of autophagy and reduced levels of amyloid plaques and phosphorylated tau.
Professor Domenico Pratico, from Lewis Katz School of Medicine at Temple University in the US, said: "This is a very important discovery, since we suspect that a reduction in autophagy marks the beginning of Alzheimer's disease.
Autophagy occurs constitutively at low levels but is accelerated by a variety of cellular stressors, such as nutrient starvation, growth factor withdrawal, DNA damage, accumulation of abnormal proteins, and organelle damage.
Autophagy is a catabolic process common to all multicellular organisms.
By promoting autophagy, it may prevent exfoliated cells from blocking the aqueous humor drainage channels of the meshwork and the Schlemm's canal.
mechanisms that permit intracellular survival, subvert autophagy process and evasion to host immune responses.