(redirected from axonal neuropathy)
Also found in: Dictionary, Thesaurus, Medical.
Related to axonal neuropathy: axonal polyneuropathy


Any disease affecting neurons.



a functional weakness of the nervous system accompanied by a decrease in the absolute threshold (also called the stimulus, or sensitivity, threshold); the condition is frequently congenital.

Neuropathy arises as a disturbance in the function of the autonomic nervous system owing to deleterious influences on the fetus as a whole (for example, infection in the pregnant mother, trauma, or poisoning) or on the individual embryonic cells (as occurs when the parents suffer from alcoholism). Family circumstances, upbringing, and illnesses suffered by the infant play a role in the pathogenesis of neuropathy. The symptoms usually emerge in childhood or adolescence. When neuropathy occurs in early childhood, disturbances of sleep and appetite are most characteristic; the infant has difficulty in falling asleep, awakes easily, suckles poorly, and frequently spits up. Later, vomiting occurs, and either diarrhea or constipation develop.

From the preschool years on, increased general excitability and the rapid onset of fatigue and exhaustion are observed, in addition to continued disturbances of sleep and appetite. Children who suffer from neuropathy blush easily in response to irritation. Motor hyperactivity, nervous tics, and stammering are frequent. In adolescence, autonomic-vascular instability becomes more acute, as evidenced by frequently occurring nervous palpitation, abrupt shifts in blood pressure, headaches, dizzy spells, and fainting spells. The prognosis is favorable, with the neuropathic symptoms usually disappearing with age.


Simson, T. Nevropatii, psikhopatii i reaktivnye sostoianiia mladencheskogo vozrasta. Moscow-Leningrad, 1929.
Sukhareva, G. E. Klinicheskie lektsii po psikhiatrii detskogo vozrasta, vol. 2. Moscow, 1959.


References in periodicals archive ?
Sensorial examination was unremarkable, and electrophysiological findings confirmed pure motor axonal neuropathy.
Subgroups of various pathological patterns of peripheral neuropathy, such as segmental demyelination, axonal neuropathy, SMON, and alcoholic neuropathy, can be differentiated from that of diabetic neuropathy on the basis of the M/F ratio.
Briani, "Reversible isolated sensory axonal neuropathy due to cobalamin deficiency," Muscle and Nerve, vol.
It is a pure motor or predominantly motor axonal neuropathy characterized by wrist drop and foot drop with minimal or no sensory loss which occurs 7-20 days after exposure to an OP agent.
Nerve conduction studies revealed severe bilateral axonal neuropathy of the median motor nerves with denervation of the proximal upper and lower extremity musculature.
The findings were suggestive of mild sensory, motor predominantly sensory axonal neuropathy.
45) In 1993, McKhann and his group having accepted this possibility suggested a new term "acute motor axonal neuropathy (AMAN)" for the condition because the disease was not exclusive to the Chinese.
This pattern of findings in the context of this patient's illness was consistent with acute motor axonal neuropathy (AMAN).
She suffered from giant axonal neuropathy - a rare genetic condition which badly affected her nervous system.
The GBS patients were classified into different subgroups according to their clinical presentation and comprised of 28 patients with acute inflammatory demyelinating polyneuropathy (AIDP), 23 with acute motor axonal neuropathy (AMAN) and 8 with acute motor sensory axonal neuropathy (AMSAN).
axonal neuropathy is characterized by a reduction in amplitude of the compound muscle action potential or compound nerve action potential, demyelination neuropathy is characterized by prolonged latency and prolonged slowing of conduction and chronic compressive lesions produce localized slowing of conduction.