axonal transport

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axonal transport

[ak¦sän·əl ′tranz‚pȯrt]

(neuroscience)

The movement of organelles and molecules down a nerve cell's axon to its terminals along its cytoplasmic microtubule network.

References in periodicals archive ?

Since this virus is disseminated by retrograde axonal transport (Hemachudha, et al.) it must first reach the cerebral cortex and from there be taken up by the axons of the mitral cells.

Entry of Rabies Virus in the Olfactory Bulb of Mice and Effect of Infection on Cell Markers of Neurons and Astrocytes/ Ingreso del Virus de la Rabia en el Bulbo Olfatorio de Ratones y Efecto de la Infeccion en Marcadores Celulares de Neuronas y Astrocitos

Yool et al., "Oligodendroglial modulation of fast axonal transport in a mouse model of hereditary spastic paraplegia," The Journal of Cell Biology, vol.

The Extracellular Environment of the CNS: Influence on Plasticity, Sprouting, and Axonal Regeneration after Spinal Cord Injury

Tau aggregates and tau missorting impair axonal transport, mitochondrial function, and cytoskeletal dynamics and elevate oxidative stress in AD in an A[sz]-independent manner.

Tau-mediated Neurodegeneration and Potential Implications in Diagnosis and Treatment of Alzheimer's Disease

Moreover, HDAC6 inhibitors reverse axonal transport deficits in mouse models of CMT2F [7] and cellular models of Parkinson's disease [10] and Huntington's disease [11] by increasing acetylated [alpha]-tubulin.

HDAC6 Inhibitors Rescued the Defective Axonal Mitochondrial Movement in Motor Neurons Derived from the Induced Pluripotent Stem Cells of Peripheral Neuropathy Patients with HSPB1 Mutation

Casson, "The optic nerve head is the site of axonal transport disruption, axonal cytoskeleton damage and putative axonal regeneration failure in a rat model of glaucoma," Acta Neuropathologica, vol.

Gene Expression Profiling of the Optic Nerve Head of Patients with Primary Open-Angle Glaucoma

(15) Neurotrophic factor deprivation induces the loss of RGCs after impaired axonal transport, (16) while neurotrophic factor supplementation reduces the loss of RGCs after optic nerve injury.

Neural stem cell-based intraocular administration of pigment epithelium-derived factor promotes retinal ganglion cell survival and axon regeneration after optic nerve crush injury in rat: an experimental study

Our approach relies on axonal transport to reach the cell bodies, whereas the in vitro approach acts directly on RGCs.

Rescuing axons from degeneration does not affect retinal ganglion cell death

Other mechanisms that have been implied in ALS, such as excitotoxicity and defective axonal transport, may be consequences of oxidative stress [60].

Is Modulation of Oxidative Stress an Answer? The State of the Art of Redox Therapeutic Actions in Neurodegenerative Diseases

(40) The axonal transport of mRNAs, their stabilization and their local translation provide the structural and regulatory proteins required for axon regeneration in mammals.

MAP kinase cascades regulating axon regeneration in C. elegans

Moreover vitrectomy blocks the axonal transport of optic nerve fibers by pulling the fibers and the optic disc-nourishing blood vessels.

Effects of timing of vitrectomy performed for open-globe injury patients on the thickness of retinal nerve fiber layer

Fast axonal transport is highly dependent on this energy.

Acute intermittent porphyria presenting as progressive muscular atrophy in a young black man

Brown, "Slow axonal transport: Stop and go traffic in the axon," Nature Reviews Molecular Cell Biology, vol.