Since this virus is disseminated by retrograde axonal transport
(Hemachudha, et al.) it must first reach the cerebral cortex and from there be taken up by the axons of the mitral cells.
Yool et al., "Oligodendroglial modulation of fast axonal transport
in a mouse model of hereditary spastic paraplegia," The Journal of Cell Biology, vol.
Tau aggregates and tau missorting impair axonal transport
, mitochondrial function, and cytoskeletal dynamics and elevate oxidative stress in AD in an A[sz]-independent manner.
Moreover, HDAC6 inhibitors reverse axonal transport
deficits in mouse models of CMT2F  and cellular models of Parkinson's disease  and Huntington's disease  by increasing acetylated [alpha]-tubulin.
Casson, "The optic nerve head is the site of axonal transport
disruption, axonal cytoskeleton damage and putative axonal regeneration failure in a rat model of glaucoma," Acta Neuropathologica, vol.
(15) Neurotrophic factor deprivation induces the loss of RGCs after impaired axonal transport
, (16) while neurotrophic factor supplementation reduces the loss of RGCs after optic nerve injury.
Our approach relies on axonal transport
to reach the cell bodies, whereas the in vitro approach acts directly on RGCs.
Other mechanisms that have been implied in ALS, such as excitotoxicity and defective axonal transport
, may be consequences of oxidative stress .
(40) The axonal transport
of mRNAs, their stabilization and their local translation provide the structural and regulatory proteins required for axon regeneration in mammals.
Moreover vitrectomy blocks the axonal transport
of optic nerve fibers by pulling the fibers and the optic disc-nourishing blood vessels.
Fast axonal transport
is highly dependent on this energy.
Brown, "Slow axonal transport
: Stop and go traffic in the axon," Nature Reviews Molecular Cell Biology, vol.