alkylamines can be obtained from the reaction of bromo alkylamine hydroboride with sodium azide or from a similar reaction with N-phthalimido bromo alkylamine followed by amine deprotection with hydrazine (Figure 28).
Catalytic hydrogenation of the azido
groups using Adams' catalyst  under atmospheric pressure with simultaneous cyclization afforded bimorpholine 1 in satisfactory overall yield (44%).
Knaus, Design and synthesis of Celecoxib and Rofecoxib Analogues as Selective Cyclooxygenase-2 (COX-2) Inhibitors: Replacement of Sulfonamide and methylsulfonyl pharmacophores by an Azido
The computational modeling places the photoactive phenyl azido
moiety of RTI-82 proximal to Phe319 in DAT.
Amino acids with azido
functions in the side chain are appreciated in organic synthesis for its ease of introduction into complex structures, convenient conversion to a primary amine , and participation in dipolar cycloaddition reactions , especially with respect to bioorthogonal reactions .
Chattopadhyay, "Synthesis and characterisation of two double EE azido
and thiocyanato bridged dimeric Cu(II) complexes with tridentate Schiff bases as blockingligands," Polyhedron, vol.