azidothymidine


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Related to azidothymidine: nevirapine

azidothymidine:

see AZTAZT
or zidovudine
, drug used to treat patients infected with the human immunodeficiency virus (HIV), which causes AIDS; also called azidothymidine. Originally developed in 1964 as an anticancer drug, AZT was never approved for that purpose.
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References in periodicals archive ?
The toxicity of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex.
Grieco et al., "The toxicity of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex.
Shortly after the identification of the virus, scientists began working on possible treatments, culminating in the first anti-viral treatment for HIV, called azidothymidine (AZT).
Since the first anti-HIV drug, GlaxoSmithKline's (GSK's) Retrovir (azidothymidine), was approved in 1987, major improvements have been made in the field of antiretroviral therapy (ART).
Development of a ceramic matrix system for continuous delivery of azidothymidine. Biomedical Sciences Instrumentation.
In this study, it was aimed to investigate the effects of a new synthetic compound, platinum azidothymidine, on inhibition of telomerase and Bcl-2 expression in hepatocellular carcinoma compared to azidothymidine.
In 1986, under pressure from AIDS groups, the agency made the unapproved investigational drug azidothymidine (AZT) available on a "compassionate use" basis to patients outside of formal clinical trials.
The late 1980s through the mid-1990s introduced antiretroviral medications such as azidothymidine, dideoxyinosine, dideoxycytidine, protease inhibitors, combination drug therapy and Highly Active Antiretroviral Therapy (HAART).
Tsoukas, "Liposomal encapsulation of azidothymidine results in decreased hematopoietic toxicity and enhanced activity against murine acquired immunodeficiency syndrome," Blood, vol.
By contrast, BNO-1055 significantly attenuated the uptake of the purine analog fludarabine and the pyrimidine analogs azidothymidine and gemcitabine.
By 1986, azidothymidine (AZT), an antiretroviral that interferes with the replication of the HIV virus, was widely prescribed because of its apparent ability to extend the life of some infected people (Strug et al., 2002).
(1987) The efficacy of Azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-Related Complex.