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Among the 19 SH-HCC cases, all showed macrovesicular steatosis, inflammation and ballooning degeneration, with Mallory hyaline in 16 of 19 cases (84.
Signs of the classic HSV cytopathic effect included the presence of intracellular proteinaceous fluid, ballooning degeneration of epithelial cells, and acantholysis (figure 2, A) as well as intranuclear inclusion bodies and a ground-glass appearance of some nuclei (figure 2, B).
Microscopically, the lesions were characterized by epidermal hyperplasia and necrosis with ballooning degeneration, and intracytoplasmic inclusions (Bollinger bodies) in keratinocytes.
Schwimmer and his associates, is a steatosis with ballooning degeneration and/or perisinusoidal fibrosis with or without lobular inflammation and without portal inflammation or fibrosis.