Indole-3-carboxaldehyde (0.145gm, 1mmol) and barbituric acid (0.128gm, 1mmol) were mixed together in the presence of 2mL IL 1 -butyl-3methylimidazolium hydroxide the reaction mixture was heated at 60[degrees]C temperature with stirring in a oil bath for appropriate time as shown in (Table 2).
Indole-3-carboxaldehyde (0.145gm, 1mmol) and barbituric acid (0.128gm, 1mmol) were mixed together in the presence of 2mL IL 1 -butyl-3methylimidazolium hydroxide in a beaker, then irradiated in a domestic microwave oven of 1100W for specific time as shown in (Table 2).
Why was Veronal active, while barbituric acid
had no effect?
To investigate whether it might be advantageous to allow for the contribution of the natural color of the urine samples to apparent TNM concentrations, we also measured the absorbance (at 506 nm, the [[lambda].sub.max], of the chromophore derived from cotinine) for 280-[micro]L aliquots of acetone/water (5:9 by vol) in place of the potassium cyanide, Chloramine-T, and barbituric acid reagents.
, quantitative variants of the Konig reaction with barbituric acid as the condensing reagent performed as well among our diabetic patients as among other previously studied groups.
The isothermal polymerizations of N, N' -bismaleimide-4, 4'-diphenylmethane (BMI) with barbituric acid
(BTA) with BTA/BMI = 1/2 (mol [mol.sub.-1]) have a reaction order of 1, the reaction rate constant in the range 3.06 X [10.sup.-2] -1.97 X [10.sup.-1] 1/min, and the activation energy of 76.3 kJ [mol.sup.-1] in the temperature range 373-403 K.
R= Barbituric acid
2-8 and Thiobarbituric acid 9-15.
Recently, barbituric acid
derivatives have als o received great interes t for applications in Nanos cience [17, 18]
Diversity in biological activities of barbituric acid
and its analogs have attracted the interest of medicinal chemists for exploring these molecules extensively.
itself is hypnotically inactive, but substitution at C-5 of the barbiturate ring makes these analogs active as central nervous system depressants.
As a further extension of this strategy, we now wish to report a convenient synthesis of 5-arylidene -barbiturates 3a-3s by way of a one pot Knoevenagel condensation between a variety of aromatic aldehydes 1a - 1s with barbituric acid
2 under solvent free conditions in presence of a catalytic amount of acetic acid (Scheme-1).
Merk), barbituric acid
, (BDH), atenolol, (Zafa) pentazocine (Searle Pak.