[35.] Kershaw R.M., Hodges N.J.: Repair of oxidative DNA damage is delayed in the Ser326Cys polymorphic variant of the base excision repair
Genetic polymorphisms in the base excision repair
pathway and cancer risk: a HuGE review.
In this paper, we study the selected polymorphisms of nucleotide excision repair (NER) and base excision repair
(BER) pathways and their impact on modulating risk of colorectal cancer occurrence.
Dogliotti, "The base excision repair
: mechanisms and its relevance for cancer susceptibility," Biochimie, vol.
Sugimura, "Role of base excision repair
enzyme MUTYH in the repair of 8-hydroxyguanine and MUTYH-associated polyposis (MAP)," Hereditary Genetics, vol.
The Ku70-deficient cell line is sensitive to oxidizing agents, and its deficiency in double-strand break repair by nonhomologous end joining, which also serves as a back-up repair pathway for the base excision repair
(BER) pathway, provides a window into the cellular responses to oxidatively induced DNA damage (Choi et al.
The company stated TRC102 (methoxyamine) is a novel, clinical-stage small molecule inhibitor of the DNA base excision repair
pathway, which is a pathway that causes resistance to alkylating and antimetabolite chemotherapeutics.
Longevity has also failed to increase in most studies with mice with overexpression of base excision repair
(BER) genes--a major pathway for repairing oxidative damage in DNA.
This polymorphism is the result of a nucleotide substitution from guanine (Arg) to adenine (Gln) (G to A), and the resulting protein is thought to affect the complex assembly of the base excision repair
apparatus or repair efficiency.13,14
Cells lacking TDG activity exhibit two major alterations: a decreased capacity for base excision repair
, leading to increased sensitivity to mutagenic damage and the accumulation of mutations, and an impaired ability to maintain wild-type promoter region methylation patterns, resulting in inappropriate gene expression.
Known as base excision repair
, it begins with the uracil-N-glycosylase enzyme, which acts to search through dsDNA for any uracil residues.