base excision repair


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base excision repair

[′bās ek′siz·zhən ri‚per]
(cell molecular)
A deoxyribonucleic acid (DNA) repair system in which an altered base is removed from the sugar backbone by action of a specific DNA glycolase and then the abasic sugar is removed by apurinic/apyrimidic (AP) lyase and AP endonuclease, leaving a one-nucleotide gap that is then filled in and ligated.
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References in periodicals archive ?
sup][4] The predominant DNA repair pathway for oxidative DNA damage is base excision repair (BER).
Genes regulated by co-exposure in these networks include members of the base excision repair (BER), the nucleotide excision repair (NER), and double-strand break repair pathways.
carthamoides root extracts is related to stimulation of CHO cells to efficient DNA repair via activation of DNA glycosylases (higher level of DNA damage at the early step of repair), involved in base excision repair, which recognize and catalyze the removal of damaged base.
At least four DNA repair pathways operate on specific types of damaged DNA: base excision repair (BER), nucleotide-excision repair (NER), mismatch repair (MMR), and double-strand break repair.
Completion of base excision repair by mammalian DNA ligases.
Identification of genetic variants in base excision repair pathway and their associations with risk of esophageal squamous cell carcinoma.
This process is therefore called base excision repair.
Base excision repair is a multi-step process that corrects non-bulky damage to bases resulting from oxidation, methylation, deamination, or spontaneous loss of the DNA base itself (Memisoglu et al.
Washington, March 26 (ANI): A new study has found that the human immunodeficiency virus (HIV), the cause of AIDS, makes use of the base excision repair pathway when inserting its DNA into the host-cell genome.
MUTYH-associated polyposis (MAP) is an autosomal recessive syndrome associated with biallelic germline mutations in the base excision repair gene MUTYH (OMIM #608456) (1).