base pairing


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Related to base pairing: complementary base pairing

base pairing

[′bās ′per·iŋ]
(cell and molecular biology)
The hydrogen bonding of complementary purine and pyrimidine bases-adenine with thymine, guanine with cytosine-in double-stranded deoxyribonucleic acids or ribonucleic acids or in DNA/RNA hybrid molecules.
References in periodicals archive ?
The error rates for natural base pairing by proofreading-deficient DNA polymerases (without 3'-exonuclease activity) range from [10.
Base pairing complementarity in polymerase reactions
Among these unnatural base pairs, the order of the efficiency and selectivity of the unnatural base pairing in T7 transcription is v-y > s-y > x-y.
Although the 98% selectivity of the unnatural base pairing is not sufficient for practical use in replication (the retention rate of the isoG-isoC pair in 20-cycle PCR amplified DNA fragments becomes around 67% (0.
We still do not know the mechanism underlying the improved fidelity of the unnatural base pairing using the [gamma]-amidotriphosphates.
This mechanism of action is similar to that of protein-based therapeutics, and is fundamentally different from the mechanism of action of antisense oligonucleotides, which relies on simple Watson-Crick base pairing to the mRNA precursor of the target.
To do this, the researchers used hybridization, the base pairing between two single strands of DNA that results in the well-known double-helix structure.