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According to the colors after HE staining, the cells could be divided into chromophobe cells, acidophil cells and basophil cells. The cytoplasmic of the acidophil cells were red, and the nuclei were deep blue.
The pathophysiology in urticaria is explained by release of vasoactive mediators from activated mast and basophil cells. Histamine is responsible of erythema, swelling and axon reaction which leads to expansion of reaction observed in urticaria.