bcl-2


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bcl-2

(biochemistry)
A family of proteins that operate in the effector phase of apoptosis and may either promote or inhibit apoptosis.
References in periodicals archive ?
Among them, Bcl-2 and Bax are the two representative members of the Bcl-2 family and are the key regulators of apoptosis in the mammalian cell.
APG-2575 could potentially be the first China-made Bcl-2 inhibitor.
"Their decision further validates our industry-leading expertise in the discovery and development of small molecules for complex and difficult-to-target protein-protein interactions including Bcl-2 and other apoptotic pathways."
The purpose of this study was to identify a polymorphism in the promoter region (-938C>A) of the BCL-2 gene.
The Bcl-2 family modulates cell apoptosis by either pro- or anti-apoptotic members.
Here, we investigate transient Bcl-2 overexpression as an effective, safe approach to achieve prolonged posttransplantation survival of CD-NSCs.
Membranes were then blocked for 1 h at room temperature with Tris-buffered saline-Tween 20 (TBS-T; 20 mM Tris-HCl (pH7.4), 137.5 mM NaCl, and 0.1% Tween 20) containing 5% skim milk, washed with TBS-T three times, and probed at 4[degrees]C for 12 h with rabbit antibodies to sheep cytochrome c (Sigma-Aldrich), human Bcl-2 (1:500 dilution; Santa Cruz Biotechnology, Dallas, TX, USA), and human Bcl-2-associated X protein (Bax; 1 : 500 dilution; Santa Cruz Biotechnology) or with goat antibodies to human [beta]-actin (1:500 dilution; Santa Cruz Biotechnology).
The Bcl-2 family includes antiapoptosis protein like Bcl-2 and proapoptosis protein like Bax.
Kaspaz aktivitesini engelleyen inhibitorler, Bcl-2 kontrol noktalarina mudahale eden molekuller, SMAC taklit eden molekuller, anti-saperon antisens ajanlarinin kullanimi, halihazirda klinik olarak degerlendirilen yaklasimlarin basinda gelmektedir (2).
The PCR primer sequences were designed according to the gene sequences reported in GenBank and were chemically synthesized: Bcl-2 (upstream: 5'-ATCCCAGCCTCCGTTAT CCT-3', downstream: 5'-ATCCCAGCCTCCGTTATCCT-3').
The procaspase-3 protein contents, and Bcl-2 mRNA and protein contents were significantly decreased while caspase-3 protein contents, and Bax mRNA and protein contents were concomitantly increased in the concentration-dependent manner in FA groups (P 0.
Various monoclonal antibodies were used to evaluate the tumor cells immunohistochemically, including antisynaptophysin, chromogranin A, estrogen receptor (ER), progesterone receptor (PgR), human epidermal growth factor receptor 2 (HER-2), bcl-2, p53, and Ki-67 antibodies.