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(MIT) 1. To fail. A program loses when it encounters an exceptional condition or fails to work in the expected manner.

2. To be exceptionally unesthetic or crocky.

3. Of people, to be obnoxious or unusually stupid (as opposed to ignorant).

4. Refers to something that is losing, especially in the phrases "That's a lose!" and "What a lose!"
References in classic literature ?
But I've never been lost before," murmured the dainty maiden, "and I'm worried and afraid.