It is an excellent replacement for formaldehyde-donors, parabens, triclosan and benzethonium chloride
The agency has deferred for 1 year a decision on the continued use of three other ingredients in consumer wash products: benzalkonium chloride, benzethonium chloride
, and chloroxylenol.
Three additional ingredients common in cleaning products --benzalkonium chloride, benzethonium chloride
and chloroxylenol --remain under review by the FDA.
13 request is directed at solutions, swabs, pads saturated with a solution, and applicators containing solutions typically including isopropyl or ethyl alcohol, povidone iodine, poloxamer-iodine, benzalkonium chloride, benzethonium chloride
, or chlorhexidine gluconate as a single agent or in combination with alcohol.
triclosan, and benzethonium chloride
have been identified in commercial GSE samples.
The reason for the adverse reaction was due to the preservative used in the liquid Benadryl, i.e., Benzethonium chloride
. This preservative is in nearly everything that sets on the shelves of stores, or one of its sister preservatives, sodium benzoate and potassium benzoate.
In all of the antimicrobial active grapefruit seed extracts, the preservative benzethonium chloride
was detected by thin layer chromatography.
Second, synthetic preservative substances, such as benzethonium chloride
, are potent inhibitors of CYP2C9 activity in vitro, producing unpredictable effects of warfarin therapy (3).
Among the aqueous solutions are ordinary water, 10% sodium bicarbonate, 3% hydrogen peroxide, 2% acetic acid, and a combination of 0.5% aluminum acetate and 0.03% benzethonium chloride
. Overall, aqueous solutions do a fairly good job of expanding and loosening or dissolving cerumen plugs.
Formaldehyde (<0.02%) is added as a stabilizer and benzethonium chloride
(0.0025%) as a preservative.
"ACI has already been sharing detailed information with FDA on five active ingredients we are supporting on behalf of our members: benzalkonium chloride, benzethonium chloride
, chloroxylenol, alcohol and povidone-iodine.
ingredients: propanol-2 alcohol or mixture of alcohols (propanol-1 and propanol-2) - not less than 70%, antimicrobial benzethonium chloride
or clathrate of quaternary ammonium compound with urea (urea) - not less than 0.10%.