In case of participants using adapalene 0.1% gel monotherapy the reduction was 28.33% and 45.83% in those using benzoyl peroxide
2.5% gel monotherapy at the end of week 12 of the study.
gels are known to work well, although foams and cleansers are available for patients who Fred them too irritating.
A recent narrative review of clinical trials concluded that clindamycin plus benzoyl peroxide
was more effective in reducing inflammatory lesions than monotherapy with either agent alone, and was similar in efficacy to benzoyl peroxide/erythromycin combination.
The azelaic acid-treated patients had 45% fewer pustules, 48% fewer papules, and 17% fewer nodules by week 12; the Benzamycin (3% erythromycin plus 5% benzoyl peroxide
) group had 33% fewer pustules, 50% fewer papules, and 25% fewer nodules.
The diperoxyketal peroxides, such as benzoyl peroxide
, are somewhat more reactive as a class than the dialkyls.
Healthcare company Perrigo Company plc (NYSE:PRGO) (TASE:PRGO) reported on Monday the receipt of the tentative approval from the US Food and Drug Administration for the generic version of Acanya (clindamycin phosphate and benzoyl peroxide
) topical gel 1.2%/2.5% for the topical treatment of acne vulgaris.
Most patients upon presentation have used the over-the-counter preparations, which usually consist of benzoyl peroxide
and salicylic acid.
The first consists of monotherapy with benzoyl peroxide
or a topical retinoid, which can be an inexpensive option.
Effaclar Duo Dual Action Acne Treatment is an over-the-counter medication that features a patent-pending combination of ingredients including micronized benzoyl peroxide
(5.5%) and lipohydroxy acid, or LHA, (0.4%).
Diacyl peroxides include several grades of benzoyl peroxide
that are in water wetted granular form and powdered form in various phthalates.
Some of the newest and best-known Stiefel brands are Duac topical gel (clindamycin, 1% benzoyl peroxide
, 5%) available in the Duac Care System; Evoclin (clindamycin phosphate) foam, 1%; Luxiq (betamethasone valerate) foam, 0.12%; MimyX cream; Olux (clobetasol propionate) foam, 0.05%, and Ohix-E (clobetasol propionate) foam, 0.05%, also available in the Olux/Olux-E complete pack; Soriatane (acitretin) capsules, available in the Soriatane CK convenience kit; Verdeso (desonide) foam, 0.05%; Brevoxyl-4 creamy wash (benzoyl peroxide
4%) and Brevoxyl-8 creamy wash (benzoyl peroxide
8%), packaged in the Brevoxyl acne wash kit; Extina (ketoconazole) foam, 2%; Oilatum cleansing bar; Physiogel cream; Stieprox (ciclopirox olamine) shampoo; Revaleskin skin care products; and Sarna lotion.