berberine


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berberine

[′bər·bə‚rēn]
(organic chemistry)
C20H19NO5 A toxic compound; melting point 145°C; the anhydrous form is insoluble in water, soluble in alcohol and ether.
References in periodicals archive ?
Alkaloid berberine is prevailing active medicinal agent.
Xiang, "Effect of jatrorrhizine, berberine, Huanglian Decoction and compound-mimic prescription on blood glucose in mice," Chinese Traditional & Herbal Drugs, vol.
Berberine and dimethyl sulfoxide (DMSO) were obtained from SigmaAldrich Chemical Inc.
Zhao et al., "Effect of berberine on acetylcholine-induced atrial fibrillation in rabbit," American Journal of Translational Research, vol.
Berberine is a quaternary plant ammonium salt extract, which has lipid-lowering, hypoglycaemic, anti-inflammatory and antihypertensive effects, beyond a low systemic bioavailability (Cicero and Ertek 2009).
A study published in the Asian Pacific Journal of Tropical Medicine reports that in lab tests, berberine (the active compound in the plant) was added to drug-resistant E.
Organically cultivated goldenseal, as well as Oregon grape root (Mahonia spp.) and barberry (Berberis spp.), all contain "berberine," an alkaloid that has potent antimicrobial activity on contact, such as when rinsing with a neti pot.
Despite a great deal of research has been undertaken during the last 10 years, None of the current drugs under clinical trials has shown yet an improvement in overall survival over existing standard therapy or solved the emergence of chemoresistance.nax035, An innovative berberine derivative has exhibited efficacy as antitumour agent with a good preliminary pharmacokinetic, Toxicity and safety data when administered as oral therapy for the treatment of malignant mesothelioma.
This plant is rich in medicinally important phytochemical constituents like berberine (Ali and Khan, 1978), umbellatine (Baquar, 1989), plamitine (Gosh et al., 1990), baluchistanamine, karakoramine, gilgitine, jhelumine, punjabine, sindamine, chinabine (Manske, 1998), berbamine (Khare, 2004), [beta]-sitosterol, 4-4,dimethylhexadeca-3-ol, Butyl-3-hydroxypropylphthalate, 3-(4'-(6-methylbutyl) phenyl) propan-1-ol (Sabir et al., 2013).
Berberine, an orangish-yellow alkaloid found at high levels in the bark and root structures of plants including Oregon grape (Mahonia aquifolium), goldenseal (Hydrastis canadensis), barberry (Berberis vulgaris), and Chinese goldthread (Coptis chinensis), has a broad and wide history of use.