Further research at UIC showed that it was possible to stop the immune attack on pancreatic Beta cells
through immunomodulation (regulating a specific immune attack on specific targets).
If the product candidate performs as intended, it has the potential to provide individuals who have T1D with a replacement for the beta cells
lost or impaired as a result of their disease.
Transcription factors in islet development and physiology: role of PDX-1 in beta cell
Diminished glucose sensing by beta cells
was an important factor in both the development and severity of the disease.
However, even in the prediabetic stage, beta cell
numbers and function are decreased.
Royal College of Surgeons' Professor Jochen Prehn said: "There is tremendous hope there is capacity to regenerate beta cells
or protect them against immune cell attack.
We will continue to work with Tolerx to further otelixizumab's clinical development and to validate its promise of beta cell
preservation in new-onset autoimmune type 1 diabetes patients.
They started with 1,100 candidate genes and narrowed the field to 28 that are involved in forming the part of the pancreas where beta cells
It is not known at this stage if the bone marrow stem cells are replacing the faulty immune system cells with ones that do not destroy the beta cells
, or if the bone marrow cells are able to support the production of new beta cells
Combined with a beta cell
growth factor, a biochemical that promotes growth, the diabetic mice were completely cured for at least four months.
In diabetes, the immune system attacks the insulin-producing beta cells
in the pancreas and destroys them.
At least eight clinical stage programs aim at limiting inflammation leading to beta cell
destruction and, thus, also preserve mass and function.