beta cell


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Related to beta cell: alpha cell

beta cell

[′bād·ə ‚sel]
(histology)
Any of the basophilic chromophiles in the anterior lobe of the adenohypophysis.
One of the cells of the islets of Langerhans which produce insulin.
References in periodicals archive ?
Sustained beta cell apoptosis in patients with long-standing type 1 diabetes: indirect evidence for islet regeneration?
Keane et al., "Glucose, palmitate and pro-inflammatory cytokines modulate production and activity of a phagocyte-like NADPH oxidase in rat pancreatic islets and a clonal beta cell line," Diabetologia, vol.
Transgenic expression of dominant-negative Fas-associated death domain protein in beta cells protects against Fas ligand- induced apoptosis and reduces spontaneous diabetes in nonobese diabetic mice.
Sections of the pancreases were stained for the endocrine beta cells with a guinea pig antiswine insulin antibody (Dako Co., Glostrup, Denmark) [11], Pdx1, and Ki67 (Abcam, California, CA).
Beta cell cytoplasm stained bluish while alpha cell cytoplasm stained pinkish andthe nuclei stained violet.
The decline in beta cell function in type 2 diabetes is in directly associated with impaired action of the incretin hormones, glucose-dependent insulinotropic polypeptide (GIP), and GLP-1.
Disruption of Tsc2 in pancreatic beta cells induces beta cell mass expansion and improved glucose tolerance in a TORC1-dependent manner.
Team leader Dr Terry Strom said: "It would appear by altering the inflammatory state that surrounds this disease, you create an environment that enables expansion of the beta cell mass."
Dr Iain Frame, Diabetes UK's research manager, said: "This research demonstrates that there may have been a substantial improvement in beta cell function.
GLP-1 stimulates pancreatic beta cells to increase the secretion of insulin, so GLP-1 has the potential to improve beta cell function itself.