Pancreatic beta cell
mass as a pharmacological target in diabetes.
Sustained beta cell
apoptosis in patients with long-standing type 1 diabetes: indirect evidence for islet regeneration?
Keane et al., "Glucose, palmitate and pro-inflammatory cytokines modulate production and activity of a phagocyte-like NADPH oxidase in rat pancreatic islets and a clonal beta cell
line," Diabetologia, vol.
Transgenic expression of dominant-negative Fas-associated death domain protein in beta cells
protects against Fas ligand- induced apoptosis and reduces spontaneous diabetes in nonobese diabetic mice.
All beta cells
contribute equally to islet growth and maintenance.
Sections of the pancreases were stained for the endocrine beta cells
with a guinea pig antiswine insulin antibody (Dako Co., Glostrup, Denmark) , Pdx1, and Ki67 (Abcam, California, CA).
cytoplasm stained bluish while alpha cell cytoplasm stained pinkish andthe nuclei stained violet.
The decline in beta cell
function in type 2 diabetes is in directly associated with impaired action of the incretin hormones, glucose-dependent insulinotropic polypeptide (GIP), and GLP-1.
Disruption of Tsc2 in pancreatic beta cells
induces beta cell
mass expansion and improved glucose tolerance in a TORC1-dependent manner.
Team leader Dr Terry Strom said: "It would appear by altering the inflammatory state that surrounds this disease, you create an environment that enables expansion of the beta cell
Dr Iain Frame, Diabetes UK's research manager, said: "This research demonstrates that there may have been a substantial improvement in beta cell
GLP-1 stimulates pancreatic beta cells
to increase the secretion of insulin, so GLP-1 has the potential to improve beta cell