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The single chain of 145 amino acids that comprises the beta subunit is unique to hCG; the alpha subunit is common to other members of the family of glycoprotein hormones to which hCG belongs, including LH, FSH, and TSH.
Early reports of cleavages (nicks) in the hCG beta subunit at positions 44-45 and/or 47-48 (5-8) have been followed by other reports relating to the extent of nicking in various hCG preparations (9) and to the biochemical and immunological characterization of nicked hCG (hCGn) (10).
Detection of the free beta subunit of human chorionic gonadotropin (HCG) in cultures of normal and malignant trophoblast cells, pregnancy sera, and sera of patients with choriocarcinoma.
It is well known that a Hb molecule adheres to the beta subunit of haptoglobin [5], but the kind of alpha subunits among haptoglobin phenotypes may affect the affinity of haptoglobin molecules to Hb [4,6].
The free beta subunit (hCG[beta]) consists of a 22-kDa polypeptide containing 145 amino acid residues, with two N-linked and four O-linked carbohydrate chains.
The interim results of the study suggest that intradermal administration of CDX-1307 results in localization of Beta subunit of human chorionic gonadotropin (Beta hCG) in antigen-presenting cells of the skin.
He and his coinvestigators concentrated on an amino acid in a beta subunit that Harrison's group and other scientists had identified as potentially important to anesthetic sensitivity.
The following RUO (Research Use Only) immunoassay kits for quantitative determination of cancer antigens are available immediately: alpha-fetoprotein (AFP); carcinoembroyonic antigen (CEA); CA125; CA15-3; CA 19-9; PSA; free PSA (f-PSA); free beta subunit of human chorionic gonadotropin (free beta-hCG) and beta-2 Microglobulin (B2MG).