glucuronidase

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glucuronidase

[‚glü·kyə′rän·ə‚dās]
(biochemistry)
An enzyme that catalyzes hydrolysis of glucuronides. Also known as glycuronidase.
References in periodicals archive ?
We found statistically significant correlations between increased resistance to 5-fluorocytosine and higher enzymatic activity of chymotrypsin and alpha-mannosidase; increased resistance to miconazole and higher enzymatic activity of beta-glucuronidase; increased susceptibility to miconazole and higher enzymatic activity of leucine arylamidase and acid phosphatase; increased susceptibility to itraconazole and higher enzymatic activity of lipase.
This discovery wasn't central to the purpose of the research, but the study published Tuesday noted the red flag it should have represented at the time: By the late 1960s, other scientific publications had found a positive association between higher levels of urinary beta-glucuronidase and bladder cancer.
Remarkably, lysosomal enzymes analyses (cord blood) showed that beta-glucuronidase activity was undetectable; this was further confirmed by subsequent cultured fibroblasts from fetal skin biopsy.
[4] This is due to guanosine monophosphate dehydrogenase and beta-glucuronidase deficiency which alters the microtubular and lysosomal function leading to incomplete elimination of bacteria from macrophages.
The main findings of the results above are the Citrobacter freundii and the Klebsiella pneumoniae, and additional finding on this same result was that of markedly elevated fecal beta-glucuronidase. With years of trial and error and a high degree of certainty based on personal experience backed by a massive review of the research literature, I would interpret the above results as follows:
Bevan, "GUS fusions: beta-glucuronidase as a sensitive and versatile gene fusion marker in higher plants," EMBO Journal, vol.
Assay for beta-glucuronidase in species of the genus Escherichia and its applications for drinking-water analysis.
Preer and Phillip (2011) highlight that some conjugated bilirubin can be turned back into unconjugated bilirubin by an enzyme called beta-glucuronidase in the intestine and this unconjugated bilirubin is reabsorbed and returned to the liver via a process called 'enterohepatic circulation'.
(30), (31) Reishi mushrooms limit the activity of beta-glucuronidase, an enzyme that is elevated in many liver conditions, including inflammation, cirrhosis, and jaundice.
The presence of six enzymes was established in parotid saliva: acid phosphatase, total esterases, cholinesterase, lipase, beta-glucuronidase, and lysozyme.

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