beta-lactamase


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beta-lactamase

[¦bād·ə ′lak·tə‚mās]
(microbiology)
A bacterial enzyme that catalyzes the hydrolysis of the lactam ring in some penicillin antibiotics, rendering them ineffective.
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References in periodicals archive ?
Pearson chi-square test was used for the comparison of gender and sample types with regard to pAmpC beta-lactamase positivity.
(26) The diversity of carbapenem resistance rate and prevalence of beta-lactamase genes in different studies may be related to geographical areas and predominant endemic bacteria, which exist in the region.
This result can be explained by better hydrolysis of carbapenem substrates by OXA-40-like and OXA-23-like beta-lactamases and less efficient by OXA-58.
Rangnekar et al from India reported, among 153 Extended-Spectrum Beta-Lactamases (ESBL) producing Klebsiella pneumoniae isolates, 54 were resistant to one of the carbapenems.
Extended-spectrum beta-lactamase infection was the most common in the female medical ward, with approximately 21% of the total isolates.
Comparatively higher occurrence of [bla.sub.ampC] (28.1%; n=9) was observed than class A type beta-lactamases. Co-occurrence for class A and C type beta-lactamases was observed in 12.5% (n=4) environmental Enterobacteriaceae isolates.
High prevalence of bla(CTX-M) extended spectrum beta-lactamase genes in Klebsiella pneumoniae isolates from a tertiary care hospital: First report of bla(SHV-12), bla(SHV-31), bla(SHV-38), and bla(CTX-M-15) in Brazil.
EFSA panel on biological hazards; scientific opinion on the public health risks of bacterial strains producing extended-spectrum beta-lactamases and/or AmpC beta-lactamase in food and food-producing animals.
Extended-spectrum beta-lactamase-producing organisms were identified based on susceptibility to aztreonam, third and fourth generation cephalosporins (cefpodoxime 8 [micro]g/mL, ceftazidime 8 [micro]g/mL) alone and/or in the presence of beta-lactamase inhibitors (ceftriaxone/clavulanic acid 2 [micro]g/mL, cefotaxime/clavulanic acid 2 [micro]g/mL, ceftazidime/clavulanic acid 2 [micro]g/mL).
Hays, "Important methodological considerations with respect to differentiation of CTXM-15 and CTX-M-28 extended-spectrum beta-lactamases," Indian Journal of Medical Microbiology, vol.
Mathee et al., "Pseudomonas aeruginosa beta-lactamase induction requires two permeases, AmpG and AmpP," BMC Microbiology, vol.