betulinic acid


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betulinic acid

[¦bech·ə¦lin·ik ′as·əd]
(organic chemistry)
C30H48O3 A dibasic acid, slightly soluble in water, ethyl alcohol, and acetone.
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Summary: Betulinic acid (triterpene) has shown an immense potential towards the development of anticancer, antiviral, antimalarial, antifungal, antioxidant and antiprotozoal agents.
Nutrients Inhibiting Molecular Targets in Cancer Cells Cod liver oil Butyric acid Vitamin D3 Iodine (Nascent) Boswellia serrata Fish oil Melatonin Turmeric (curcumin) Ascorbic acid Nicotinamide Sodium selenite Lactoferrin Nutrients Effective in Mitochondrial Targets of Cancer Cells Beta carotene Alpha tocopherol succinate Retinoic acid Quercetin Betulinic acid Flavin has developed therapies for many diseases, including autoimmune diseases, rheumatoid arthritis, and viral diseases.
Keywords: Atherosclerotic cardiovascular disease, betulinic acid, simvastatin, high fat diet, high density lipoproteins, total cholesterol.
Caption: FIGURE 1: The representative M[S.sup.2] spectrum of (a) spinosin; (c) 6"'- feruloylspinosin; (e) jujuboside A; (g) jujuboside B; (i) camelliaside B; and (k) betulinic acid, and MRM chromatograms of (b) spinosin; (d) 6"'-feruloylspinosin; (f) jujuboside A; (h) jujuboside B; (i) camelliaside B; and (l) betulinic acid of six analytes in reference standards under experimental conditions.
In the present study, we demonstrated that helicteric acid (HA), oleanic acid (OA), and betulinic acid (BA), three triterpenes from HT, possessed anti-CRC effects through decreasing inflammation, inhibiting cell proliferation, and promoting apoptosis of HT-29 cells through their action on both NF-[kappa]B and STAT3 pathways.
Medema, "Broad in vitro efficacy of plant-derived betulinic acid against cell lines derived from the most prevalent human cancer types," Cancer Letters, vol.
Lipophilic triterpene acids, such as oleanolic acid (OA) and betulinic acid (BA), represent another group of mistletoe-derived substances with known cytotoxic effects.
Several triterpenoids, including ursolic and oleanolic acid, betulinic acid, celastrol, pristimerin, lupeol, and avicins have been reported to possess anticancer activity (Petronelli et al., 2009).
Betulinic acid (5): Ethyl acetate solutions of combined major fractions "L", "M" and "N" (fractions 39-48) were pooled and evaporated to dryness to give a green residue ([congruente con] 4.72 g), which was filtered through a Sephadex LH-20 column packed in methanol; the eluted solution obtained was reduced "in vacuo" until a solid precipitated and this was then filtered off and recrystallized from methanol yielding pure white flakes; m.p.
Isolation of betulinic acid and 23- dihydroxylean-12-en-28-oic acid from the leaves of Callistemon linearis.