A novel bibenzyl
compound (20C) protects mice from 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine/Probenecid toxicity by regulating the a-synuclein-related inflammatory response.
* CHINA: The Kunming Institute of Botany (KIB), an affiliate of the Chinese Academy of Sciences (CAS) and one of the world's leading phytology institutes, has discovered the healing qualities of Erianin bibenzyl
, a natural compound found in dendrobium.
Previous phytochemical studies of this genus yielded; dihydroisocoumarins, benzyl phthalides, favonoids, lignans, neolignans, bibenzyl
derivatives, phenolic acid derivatives, kavalactones, sesquiterpenes and triterpenes (Sari 2012; Granica et al.
Recent advances in phytochemistry of bryophytes-acetogenins, terpenoids and bis (bibenzyl
)s from selected Japanese, Taiwanese, New Zealand, Argentinean and European liverworts.
Wang et al., "Discrimination of the rare medicinal plant Dendrobium officinale based on naringenin, bibenzyl
, and polysaccharides," Science China Life Sciences, vol.
cannabinoid from the New Zealand liverwort Radula marginata.
Xu, "Simultaneous determination of phenols (bibenzyl
, phenanthrene, and fluorenone) in Dendrobium species by high-performance liquid chromatography with diode array detection," Journal of Chromatography A, vol.
The major active constituent in few Dendrobium genera which has been isolated previously by using high performance liquid chromatography-diode array detection (HPLC-DAD) method was phenols that consist of bibenzyl
, phenanthrene, and fluorenone .
The bisbibenzyl marchantin A (1) and the bibenzyl
combretastatin A-4 (3) are structurally related (Fig.
Dendrobium officinale contains a kind of bibenzyl
and a kind of phenanthrene identified in D.
The genus Lepidozia belonging to the Porellaceae family of the Class Hepaticae (liverworts) is mainly distributed in tropical and subtropical regions of the southern hemisphere and its species are rich sources of various types of secondary metabolites including isobicyclogermacranes, lepidozanes, cadinanes, eudesmanes, maalianes, vitranes, and bibenzyls
(Asakawa et al., 2012).
Furthermore, a series of aromatic compounds, such as bibenzyls
and fluorenones, were reported to be isolated from D.