The rate limiting step in bile salt
excretion is transport at the canalicular membrane, as there is a high concentration gradient to overcome in order to excrete bile salts
into the bile acid pool.
Human drug-induced liver injury severity is highly associated to dual inhibition of liver mitochondrial function and bile salt
The researchers sequenced stool microbial components and conducted bile salt
The bile salts
concentration was 2.4 mM in the aspirates used in the present study, whereas, the aspirates used by Devle et al.
The investigators found similar plate counts between ALG and POPL microcapsules when they were exposed to bile salts
. This suggests that an extra coating of POPL could be readily broken down by bile salts
commonly found in the lower gastrointestinal tract.
In the study, the children with cancer had inherited a faulty gene from both parents which stopped a protein, called bile salt
export pump (BSEP), being produced.
Therefore, in this investigation, we studied the effect of [alpha]-asarone on the activity of hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase), the rate-limiting enzyme in cholesterol biosynthesis, and on the balance between circulating lipoproteins-cholesterol level and bile secretion, as well as on the levels of cholesterol, phospholipids and bile salts
secreted in bile, in order to find evidences to support a possible mechanism of action of [alpha]-asarone related to its hypocholesterolemic and cholelitholytic effects in hypercholesterolemic rats.
It appeared that for fasting conditions, approximately 25% of the PCBs were sorbed to bile salt
micelles, 15% to digestive proteins, and 60% were still sorbed to the soil.
About 16 enzymes are needed to convert cholesterol to bile salts
. Hepatocytes also conjugate bile salts
with glycine or taurine.
However, certain components in these media such as bile salts
and phospholipids raised suspicions regarding the possible toxic effects on cell lines (Ingels and Augustijns 2003; Birch et al.
Swarming of P mirabilis can also be inhibited on media like Deoxycholate citrate agar (DCA) and MacConkey agar which contains bile salts
. In the present study imipenem, cefixime and amikacin used to prevent the swarming of P.