As phosphatidylcholine comprises over 90% of the total bile phospholipids content, (119) inadequate intake contributes to impaired biliary excretion
of bile and toxins, and promotes cholesterol crystallization and gallstone formation.
Here, we present the results of preclinical PET imaging studies performed to assess the potential of [[sup.18]F]LCATD to image in vivo the effects of rifamycin SV and sodium fusidate on hepatic uptake and biliary excretion
when coadministered via bolus injection.
Mitoxantrone is a specific substrate of BCRP , and changes in the expression and transport activity of BCRP in the liver directly affect the biliary excretion
of mitoxantrone .
Role of glutathione and hepatic glutathione S-transferase in the biliary excretion
of methyl mercury, cadmium and zinc a study with enzyme inducers and glutathione depletors.
It is concluded that ICY can be easily absorbed into the body, and then rapidly conversed to its conjugated metabolites, and finally removed from the body mainly by biliary excretion
In addition to urinary and biliary excretion
, as to blood concentration after oral administration, the complexed (conjugated form) absorbability of I was shown.
Liver masses, both benign and malignant, received attention, with the increasing value of hepatocyte-specific MRI agents in focal nodular hyperplasia; increasing accumulation of this contrast implies biliary excretion
and hence functional hepatocytes.
From the results it seemed that concurrent silymarin administration (four hours earlier) reduced the biliary excretion
Measures of biliary excretion
are bilirubin, AP, and GGT.
It has an approximate 4% biliary excretion
and can be used as an adjunct to the normal examination, with the addition of delayed imaging approximately 1 hour after the initial injection.
PCBs can enhance liver metabolism of thyroid hormone, which increases biliary excretion
, or interfere with serum proteins that bind and transport thyroid hormone.
of 3[beta]-[[sup.18]F]FCDCA is visually slower than 3[beta]-[[sup.18]F]FGCA (20-60 minutes after injection).