biological half-life


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biological half-life

[¦bī·ə¦läj·ə·kəl ′haf ‚līf]
(physiology)
The time required by the body to eliminate half of the amount of an administered substance through normal channels of elimination.
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Studies have shown the biological half-life of manganese in the human body against 20-40 days, and after this period the amount of manganese in the workplace decreased or normal serum level would return.
The physical half-life of caesium-134 is 2.0652 years, whereas, is biological half-life ranges from 20 to 60 days [12, 13].
In the 3 seropositive 6-month-old infants, the biological half-life of EV71 neutralizing antibodies was calculated as 39 and 42 days by using cross-sectional and longitudinal analyses, respectively.
This technology is designed to improve the stability, biological half-life and immunologic characteristics of therapeutic proteins naturally.
Lipoxen's PolyXen protein drug delivery technology links therapeutic proteins, or peptides, to the naturally occurring polymer polysialic acid to prolong protein stability and biological half-life, and to improve solubility and immunological characteristics while maintaining biological activity and minimizing toxicity.
NO* has a short biological half-life and is rapidly converted into its stable metabolites, nitrite and nitrate (1,2).