biotransformation


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biotransformation

[¦bī·ō‚tranz·fər′mā·shən]
(biochemistry)
The series of chemical reactions that occur in a compound, especially a drug, as a result of enzymatic or metabolic activities by a living organism.
References in periodicals archive ?
Isobionics can rightly claim to be the first company to have targeted a molecule rationally for synthesis using biotransformation technology," notes Frost & Sullivan Research Analyst Dr.
Practical methods for biocatalysis and biotransformations.
The proposed mechanism (Scheme 2) for the formation of product A involving radical intermediates could also explain biotransformation of ingested halogenated compounds in organisms.
With Isentris, pharmacologists and medicinal chemists can now explore metabolic biotransformation pathways in ways previously not possible.
But, even if the exact intake levels are known, the biological 'dose' will vary greatly between individuals because of genetic variability affecting either the absorption, biotransformation, metabolism, distribution or elimination of a nutrient or food bioactive.
Smoking, genetic polymorphisms in biotransformation enzymes, and nonsyndromic oral clefting: a gene-environment interaction.
Environmental biotransformation and accumulation in the aquatic environment has led to relatively high levels of certain camphechlor congeners in (wild and farmed) fish," added EFSA.
The North-East now has about 50 biotechnology companies, and the industrial capability of the region includes diagnostics, informatics, bio- manufacturing, biocatalysts, biotransformation, bioremediation, pharmaceutical research, microbiological analysis and testing, and production of antibodies and peptides.
Sulfoconjugation is an important pathway in the phase II biotransformation of many endogenous and exogenous compounds.
ABSTRACT--The analysis of pollutants and their metabolites resulting from biotransformation is important to studies of bioremediation or toxicology of environmental toxicants.