biotransformation


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biotransformation

[¦bī·ō‚tranz·fər′mā·shən]
(biochemistry)
The series of chemical reactions that occur in a compound, especially a drug, as a result of enzymatic or metabolic activities by a living organism.
References in periodicals archive ?
The biotransformation of nerol (74) and geraniol (77) (Demyttenaere et al.
They are the inventors of the cellulose-to-starch biotransformation, which is covered under a provisional patent application.
Table CYP450 enzymes involved in biotransformation of SSRIs SSRI Enzymes involved in biotransformation Citalopram CYP2C19, CYP2D6, CYP3A4 Escitalopram CYP2C19, CYP2D6, CYP3A4 Fluoxetine CYP2D6, CYP2C9, CYP2C19, CYP3A4 Paroxetine CYP1A2, CYP2D6 Fluvoxamine CYP2D6, CYP3A4 Sertraline CYP2C9, CYP2C19, CYP2D6, CYP3A4 CYP: cytochrome P450; SSRI: selective serotonin reuptake inhibitors Source: Reference 10 Because suicidality may be caused by inadequately treated depressive illness, MDD patients who are UMs may be more likely to commit suicide because of suboptimal antidepressant levels.
(2003) demonstrated that the scallop Chlamys nobilis and the green-lipped mussel Perna viridis exposed to Alexandrium tamarense differ in their depuration kinetics, biotransformation, and tissue distribution of PSP toxins.
This paper focuses on different mycotoxins of agricultural importance, their effects on animal health and explores the potential role of ruminants in mycotoxin biotransformation.
Papa and colleagues addressed the development, validation, and application of QSARs for the prediction of PBT and biotransformation properties of thousands of chemicals (Papa et al., 2014, 2018).
It is also important to consider the essential oil being prescribed and the synergistic, epigenetic, and biotransformation properties of both the essential oil and the individual.
The role of CYP3A4 in the biotransformation of bile acids and therapeutic implication for cholestasis.
However, with the advancement of technology and increasing food science developments, bio-tech flavor found its use for biotransformation of flavor compound.
Liver plays an important role in the uptake, biotransformation and detoxification of pollutants and pathogens and HSI reflects the fish health status.
We deem that this topic appears extremely interesting, but at the same time controversial: it is known that NAT2 enzyme has a critical role in the initial biotransformation of multiple xenobiotic substances (among all aromatic amines and hydrazines) and that several polymorphisms and alleles of its gene characterize the genome of general population (with different distribution in the world) (2).
Moreover, the biotransformation of MC via GST by conjugation with reduced GSH has been reported in aquatic organisms (Wiegand & Pflugmacher 2005, Ortiz-Rodriguez & Wiegand 2010, Pham et al.