bipolar disorder

(redirected from bipolar disease)
Also found in: Dictionary, Thesaurus, Medical.
Related to bipolar disease: schizophrenia

bipolar disorder,


manic-depressive disorder



severe mental disorder involving manic episodes that are usually accompanied by episodes of depressiondepression,
in psychiatry, a symptom of mood disorder characterized by intense feelings of loss, sadness, hopelessness, failure, and rejection. The two major types of mood disorder are unipolar disorder, also called major depression, and bipolar disorder, whose sufferers are
..... Click the link for more information.
. The term "manic-depression" was introduced by the German psychiatrist Emil KraepelinKraepelin, Emil
, 1856–1926, German psychiatrist, educated at Würzburg (M.D., 1878). He also studied under Wilhelm Wundt in Leipzig, and was appointed professor of psychiatry at the Univ.
..... Click the link for more information.
 in 1896. The manic phase of the disorder is characterized by an abnormally elevated or irritable mood, grandiosity, sleeplessness, extravagance, and a tendency toward irrational judgment. During the depressed phase, the person tends to appear lethargic and withdrawn, shows a lack of concentration, and expresses feelings of worthlessness, self-blame, and guilt. This dual character of the disorder has given it the name bipolar disorder, in contrast to the unipolar depression symptomatic of the majority of mood disorders. The symptoms range in intensity and pattern and may not be recognized at first. Individuals suffering from bipolar disorder may have long periods in their lives without episodes of mania or depression, but manic-depressives have the highest suicide rate of any group with a psychological disorder.


Estimates suggest that about 2 million Americans suffer from bipolar disorders. Symptoms usually appear in adolescence or early adulthood and continue throughout life. The disorder occurs in males and females equally and is found more frequently in close relatives of people already known to have it.. It has had notable incidence among creative individuals, affecting such artists as Hector Berlioz, Gustav Mahler, Ernest Hemingway, and Virginia Woolf.


Therapy includes lithiumlithium
[Gr.,=stone], metallic chemical element; symbol Li; at. no. 3; interval in which at. wt. ranges 6.938–6.997; m.p. about 180.54°C;; b.p. about 1,342°C;; sp. gr. .534 at 20°C;; valence +1. Lithium is a soft, silver-white metal.
..... Click the link for more information.
 (to control mania and stabilize mood swings), anticonvulsant drugs such as valproate and carbamazepine, and antidepressantsantidepressant,
any of a wide range of drugs used to treat psychic depression. They are given to elevate mood, counter suicidal thoughts, and increase the effectiveness of psychotherapy.
..... Click the link for more information.
. Electroconvulsive therapyelectroconvulsive therapy
in psychiatry, treatment of mood disorders by means of electricity; the broader term "shock therapy" also includes the use of chemical agents. The therapeutic possibilities of these treatments were discovered in the 1930s by Manfred Sakel, a Polish
..... Click the link for more information.
 has been useful in cases where other treatments have had little success. Psychotherapy can provide support to the patient and the family.


See F. K. Goodwin and K. R. Jamison, Manic-Depressive Illness (1990); D. Healy, Mania: A Short History of Bipolar Disorder (2011); publications of the National Institute of Mental Health.

bipolar disorder

[bī′pō·lər dis′ȯrd·ər]
A major affective disorder in which there are episodes of both mania and depression. Also known as manic-depressive illness.
References in periodicals archive ?
Since then, the dietary balance of omega-3s has been associated with a wide range of conditions, including the brain disorders of schizophrenia, bipolar disease, depression, Alzheimer's disease, and ADHD, and such inflammatory diseases as arthritis and cardiovascular disease, as well as obesity and diabetes.
Like people suffering from bipolar disease who love the manic phase of their ailment, Albertans are hesitant to give up the current high of their boom and bust economy.
Even though the diagnosis rests with mania and hypomania, bipolar disease is primarily a disease of depression.
Valnoctamide and its individual stereoisomers have been shown to be active in a number of preclinical models and have the potential to treat epilepsy, bipolar disease and neuropathic pain.
Some people who have diabetes or bipolar disease may not be able to tolerate steroids.
Robert was diagnosed 20 years ago with bipolar disease.
Further analysis of data collected in the survey showed that people who met any of the three criteria for bipolar disease reported an average of 50 days a year when they were unable to work effectively, either because they were absent from work (absenteeism) or because of problems they had at work ("presenteeism").
But there is evidence that the gay blade suffered from some form of bipolar disease.
Further complicating management is the fact that the Food and Drug Administration has not approved for use during pregnancy any of the psychotropic medications used to treat bipolar disease, because these agents diffuse across the placenta.
By doing so, we discovered an area not previously thought to be involved in bipolar disease in the right parietal white matter of the brain, where I identified abnormalities between people with different types of bipolar disease.
The specificity and reliability of the findings were documented by their high statistical significance, their replication in two different groups of schizophrenia patients, and the lack of such changes in neurons either from non-afflicted subjects or from patients with bipolar disease or depression.